- Open Access
Population screening for hereditary and familial cancer syndromes in Valka district of Latvia
Hereditary Cancer in Clinical Practice volume 8, Article number: 8 (2010)
The growing possibilities of cancer prevention and treatment as well as the increasing knowledge about hereditary cancers require proper identification of the persons at risk. The aim of this study was to test the outcome of population screening in the scientific and practical evaluation of hereditary cancer.
Population screening for hereditary cancer was carried out retrospectively in a geographic area of Latvia. Family cancer histories were collected from 18642 adults representing 76.6% of the population of this area. Hereditary cancer syndromes were diagnosed clinically. Molecular testing for BRCA1 founder mutations 300 T/G, 4153delA and 5382insC was conducted in 588 persons who reported at least one case of breast or ovary cancer among blood relatives.
Clinically, 74 (0.40%; 95% confidence interval (CI): 0.32 - 0.50%) high-risk and 548 (2.94%, 95% CI: 2.71 - 3.19) moderate-risk hereditary cancer syndromes were detected covering wide cancer spectrum. All syndromes were characterised by high cancer frequency among blood relatives ranging 8.6 - 46.2% in contrast to spouse correlation of 2.5 - 3.6%. The mean age of cancer onset ranged 38.0 - 72.0 years in different syndromes. The BRCA1 gene mutations were identified in 10 (1.7%; 95% CI: 0.9 - 3.1%) probands. Families with established BRCA1 gene founder mutations were identified with the frequency 1:2663 clinically screened persons.
Population screening is a useful practical tool for the identification of persons belonging to families with high frequency of malignant tumours. The whole hereditary and familial cancer spectrum along with the age structure was identified adjusting follow-up guidelines. Another benefit of the population screening is the possibility to identify oncologically healthy persons belonging to hereditary and familial cancer families so that appropriate surveillance can be offered. Clinical diagnostics is appropriate for population screening purposes; molecular investigation provides additional information. In collaboration with family doctors, the screening is technically manageable as characterised by high compliance.
Development in cancer research has brought not only expanding knowledge of cancer biology but also improved treatment results. Even thought the number of cancer deaths has decreased by 9% in the European Union (EU) between 1985 and 2000, oncological diseases remain an important cause of mortality and morbidity . The number of death due to cancer was estimated 1.12 million in the EU in 2000 . It has been proven that hereditary background can be found for practically all cancers . In 5-10% of common cancers, this hereditary basis represents an inherited single gene mutation with high penetrance . The cancer risk for a healthy person can rise significantly in the presence of a pathogenic mutation with high penetrance . Furthermore, hereditary cancers arise early in life [4, 5] and naturally affect several blood relatives. Thus, hereditary cancer determines part of the excessive risk conferred by positive family history of concordant cancer [6–10] making the family history a predictive factor. In order to prevent this group of tumours, people at increased hereditary cancer risk need to be identified earlier. However, this requires a well-planned strategy and the essential tools for detection of people at high risk.
The scientific methods of identifying the hereditary basis of a cancer include analysis of family cancer history as well as molecular tests in order to reveal pathogenic high-penetrance mutations [4, 5]. The cancer family history practically can reveal to identify cancer family syndromes characterized by monogenic dominant inheritance pattern with high penetrance. It can be subjected to various bias like denial of serious problems, lack of sufficient knowledge, poor compliance, inability to express the information correctly and others. The suggestion to check the family history data provided by the patient is reasonable . However, high accuracy of reporting cancers, reaching 83% for first-degree relatives, has been described [12, 13]. The molecular genetic testing provides objective data but can be impeded by sensitivity restrictions and presence of new or unknown mutation. Thus, absolute efficiency of any screening program cannot be expected.
The best known approach in order to identify hereditary cancer is careful analysis of the family cancer history and search for mutations in a patient receiving tumour treatment . Thus, the healthy family members gain the possibility to estimate their own cancer risk and undergo appropriate diagnostic procedures. Within the present article, this approach is designated in short as hospital screening. Population-based hospital screening provides an insight into the importance of the problem in the local population. An alternative way to detect hereditary cancer is individual testing of persons inquiring about their own cancer risk. This may lead to early diagnostics and/or psychological support.
The third alternative for the diagnostics of hereditary cancer is the population screening - the strategy that targets the whole adult population within a region in order to find out families with increased cancer risk. Hypothetically, the benefits of such approach include revealing of persons at risk before the tumour development. Also, all possible hereditary cancer syndromes can be diagnosed independently of the predominant location. However, population screening demands time, experienced staff and financial resources. Results on population screening for hereditary cancer are very limited .
The aim of this study was to test the population screening approach and its success in detecting hereditary cancer in the northeast of Latvia.
The investigation was designed as population screening for hereditary cancer in the Valka district - a geographical area in the northeast of Latvia (Figure 1). Family cancer histories were collected from 18642 adult inhabitants of Valka district representing 76.6% of the adult population. The study was carried out in close collaboration with family physicians from September 2005 until June 2007. All people were enrolled in the study regardless of gender, ethnicity or health status.
Information on family cancer history was collected using a questionnaire that was previously tested in hospital screening . The participants were asked if his/her blood relatives have had any tumour. In case of an affirmative answer, the participants were asked for the localisation of the tumour and the age of patient at the time of tumour diagnosis. If the patient has died because of the tumour the age at death was recorded as well. In order to verify the presence and location of malignant tumour, information was retrieved (if available) regarding the treatment modalities (e.g. radiation therapy and chemotherapy, extent of operation). The interview took an estimated 45 minutes to complete.
The filled-in questionnaires were analysed by physicians with experience in hereditary cancer diagnostics. The applied diagnostic criteria of the hereditary and familial cancer syndromes are presented in Table 1. Within the frames of the present study, cases corresponding to strict criteria [15, 16] were classified into group 1 (g1), but cases diagnosed by more relaxed criteria - into group 2 (g2). The combined group was designated g3.
Patients diagnosed with any hereditary cancer syndrome were invited for additional consultation in order to confirm the diagnosis and to discuss the possibilities of molecular diagnostics. Mutually related families were identified in order to prevent repeated inclusion of any affected person in further calculations.
The study was approved by the Central Commission of Medical Ethics of Latvia. Written informed consent was obtained from all patients.
The statistic evaluation was carried out by CIA software . The population prevalence of any hereditary cancer syndrome was calculated as the ratio between the number of clinically diagnosed individuals and the whole group. The frequency of cancer among blood relatives was estimated. Size of family was characterised by number of blood relatives in the affected genetic line. The course of malignant tumour was characterised by the data about the age of tumour diagnostics and age of tumour-related death. Using the data about the total number of cancers reported in the kindred by all recruited persons and the number of cancers in the families affected by hereditary cancer syndrome, the hereditary cancer burden was calculated for each location.
Molecular examination for the BRCA1 founder mutations 300T/G, 4153delA and 5382insC as described by Gorski et al.  was offered to the participants of the study reporting at least one case of breast or ovarian cancer in their family history. The molecular examination was provided for 588 patients.
The population screening by clinical criteria identified 74 (0.40%; 95% confidence interval (CI): 0.32 - 0.50%) hereditary cancer cases of group 1. Hereditary gastric cancer (HGC) was the most common syndrome, followed by familial lung cancer (FLC) and hereditary non-polyposis colorectal cancer (HNPCC) syndromes (Figure 2). In addition, 548 (2.94%, 95% CI: 2.71 - 3.19%) probands reported family history corresponding to group 2 criteria (Table 2). Here, breast and ovarian cancers were dominating locations, followed by lung cancer (Figure 3). Renal and testicular cancers were among the locations not reported by the applied criteria. The population prevalence of each hereditary and familial cancer syndrome ranged 0.005 - 0.11% in group 1 and 0.05 - 1.18% in group 2 (Table 2).
The identified pedigrees of hereditary and familial cancer syndromes were characterised by generally high frequency of malignant tumours among the blood relatives as shown in Table 2. The highest cancer frequency was recorded in the following groups: HEC/g1 (41.5%, 95% CI: 27.8 - 56.6%), the whole hereditary and familial endometrial cancer group (41.0%, 95% CI: 36.1 - 46.2%), HNPPC/g1 (30.1%, 95% CI: 23.3 - 38.0%), FLC/g1 (25.5%, 95% CI: 19.3 - 32.8%) and HGC/g1 (25.2%, 95% CI: 20.6 - 30.4%). In contrast, the spouse correlation was as low as 2.5% (95% CI: 0.7 - 8.6%) in FLC/g3 families and 3.6% (95% CI: 1.2 - 10.1%) in HGC/g3 families.
Comparison of cancer frequency between groups 1 and 2 was carried out for each location. For some locations statistically significant difference was found confirming the patient stratification. Thus, in case of HNPCC and HGC the cancer frequency was 30.1% (95% CI: 23.3 - 38.0%) vs. 15.5% (95% CI: 11.6 - 20.3%) and 25.2% (95% CI: 20.6 - 30.4%) vs. 16.0% (95% CI: 13.8 - 18.5%), respectively. The importance of both g1 and g2 proper identification was demonstrated by following data. Close frequencies of colorectal cancer was observed in HNPCC/g1, HNPCC/g2 and FCC/g2, namely 15.8% (95% CI: 10.7 - 22.5%), 10.6% (95% CI: 7.4 - 14.8%) and 17.0% (95% CI: 12.8 - 22.3%). Similarly, individual syndromes of hereditary or familial endometrial cancer showed close frequencies of endometrial cancer although significant difference was observed among combined g1 and g2 endometrial cancer syndromes (Table 2).
The health status of the probands was analysed as one of the major aspects characterising both the population screening approach, and particular hereditary cancer syndromes (Table 2). Low frequency of the affected probands was recorded in FLC (0%, 95% CI: 0 - 3.5%), in FBT (0%, 95% CI: 0 - 16.8%), in HGC (1.1%, 95% CI: 0.2 - 5.7%) as well in FBlaC (0%, 95% CI: 0 - 25.9%). The highest frequency of affected probands was observed in HPC (22.2%, 95% CI: 16.5 - 29.0%) and in the whole group of hereditary and familial endometrial cancer (14.3%, 95% CI: 7.4 - 25.7%).
There was statistically significant difference between the size of family diagnosed with a group 1 or 2 hereditary cancer syndrome and families with non-diagnostic findings (Table 3).
The mean age of cancer diagnostics and cancer-related death is presented in Table 4. The lowest mean age of cancer diagnostics was found in HBC1/g2 (38.0 years, 95% CI: 36.2 - 39.7 years), at least partially due to the selection criteria. The mean age was low in FBT (43.9 years, 95% CI: 35.0 - 52.8 years) and in FHemT (47.5 years, 95% CI: 38.9 - 56.1 years), at least partially due to the cancer occurrence in childhood. The mean age was below 50 years in few other groups: HBC/g1 (47.5 years, 95% CI: 37.1 - 57.8 years), in HEC/g2 (48.5 years, 95% CI: 44.4 - 52.6 years), in HBOC1/g2 (48.8 years, 95% CI: 44.2 - 53.3 years), in HOC/g1 (49.7 years, 95% CI: 4.0 - 95.4 years) and in HNPCC/g1-related endometrial cancer (48.4 years, 95% CI: 43.4 - 53.4 years). FBlaC/g3 was characterised by high mean age of tumour diagnostics (70.7 years, 95% CI: 66.7 - 74.7 years, respectively) as well as HPC/g1 (72.0 years, 95% CI: 67.0 - 76.9 years) and FCC/g2 (72.0 years, 95% CI: 67.3 - 76.7 years). The proportion of cases occurring before the age of 50 was statistically significantly higher in the hereditary group than in whole population for colorectal, endometrial, breast, lung cancer and haematological tumours (Table 5).
The hereditary cancer burden by location is shown in Table 6. All the most frequent cancer locations are characterized by hereditary cancer burden exceeding 10% at group 3 level. The hereditary cancer burden averaged 2.4 - 4.7% for frequently encountered tumours as colorectal, endometrial, ovarian, lung and gastric cancer in group 1.
During the population screening in Valka district 10 BRCA1 gene mutations in 7 families were found, representing 1.7% (95% CI: 0.9 - 3.1%) of the molecularly screened group, and 0.05% (95% CI: 0.03 - 0.1%) of the screened Valka population. None of the mutation carriers was diagnosed by clinical criteria of group 1 (Table 7).
The frequency of breast cancer in BRCA1 founder mutation carriers was 20%; 95% CI = 5.7 - 51.0] but in tested mutation-negative probands - 10.6% (95% CI = 8.3 - 13.3%). The corresponding incidence rates were 657.9 (95% CI = 79.7 - 2376.5) and 221.8 (95% CI = 169.7 - 284.9) per 100 thousands. There were no ovarian cancer cases in BRCA1 mutation carriers, corresponding to the frequency 0% (95% CI = 0 - 27.8%) and incidence rate 0 (95% CI = 0 - 1213) per 100 thousands. In BRCA1-mutation negative persons the frequency of ovarian cancer was 1.2% (95% CI = 0.6 - 2.5%) and incidence rate - 25.4 (95% CI = 10.2 - 52.4) per 100 thousands.
For many cancer locations, epidemiologic data suggest that positive family history is a risk factor [6–10]. The identification of the responsible genes and mutations is a major achievement of medical science providing the final evidence of the hereditary nature of a subgroup of cancers as well as practical tool for risk evaluation. However, the molecular analysis is complicated due to genetic heterogeneity, involving unknown mutations and genes, as well as multifactorial inheritance . Technological factors can influence the testing as even sensitive techniques have less than 90% sensitivity for all possible mutations and large deletions can be missed by sequencing . For some tumours, e.g. lung cancer , only the susceptibility loci are identified. Despite the lack of comprehensive molecular proof the hypothesis of risk group identification by family history  seems reasonable and desirable for cancer eradication.
Against this background the population screening for hereditary cancer is a rather novel approach. It is embarrassed by difficulties including variability of diagnostic criteria  and lack of comprehensive molecular genetic testing.
To our best knowledge, only one study on population screening for hereditary cancer  is published as yet. In this study carried out in the West Pomeranian region of Poland family cancer history of 1.2 million individuals was evaluated by questionnaire. So results presented in this paper are of great interest. However, further studies with extended statistical analysis are desirable. Expanding the design of population screening, originally provided by Gronwald et al. , we have analysed the age of cancer development as well as cancer frequency among blood relatives, health status of probands and hereditary cancer burden by location. The obtained data have both practical significance in cancer prevention and scientific novelty presenting the full spectrum of hereditary cancers.
The performed population screening yielded reasonable number of hereditary and familial cancer syndrome diagnoses. As comprehensive mutation analysis is not possible at the present the high frequency of index cancer among blood relatives in the identified groups can be considered as a risk indicator and also as an evidence of the expedience of the applied criteria. We tested 2 sets of criteria - strict and more relaxed one paralleling the published approach . Both sets identified families with high cancer frequency; therefore we recommend these criteria to identify persons for primary and secondary prevention and surveillance. However, further studies will probably limit the follow-up group as our study had a major drawback: due to historical reasons, older medical documentation was not available necessitating elaborating simple questionnaire in accordance with the reported acceptable rate of accurate reporting cancer in relatives .
The clustering of cancer can occur due to chance. The familial risk can also be attributed to hereditary mutations or shared environment and lifestyle factors including heritability of lifestyle. In our study, the spouse correlation in such locations as lung or gastric cancer with significant role of known environmental risk factors [7, 20] was lower than the frequency of cancer among blood relatives pointing towards the presence of genetic background.
The majority of the identified probands were healthy people. This approach using simple questionnaire helps to identify healthy persons belonging to families with a high frequency of particular malignant tumours. Surveillance should be advised for most of these people as follow-up is available for several common syndromes, and early diagnostics may have general benefit in reduction of mortality. Furthermore, during population cancer screening in Valka district the mean age of familial cancer onset in different locations was determined facilitating planning of prophylactic health check-up. The crucial value of population screening relies not only on surveillance but also on prevention and adjusted treatment options in the case of established hereditary cancer [21, 22]. Prophylactic surgical intervention is possible only after objective verification of the diagnosis .
The full spectrum of hereditary cancers was revealed including breast, lung, stomach, large bowel and endometrium as main primary locations. The high proportion of breast, colorectal and gastric cancer among the familial cancers is similar to the findings in Poland . Notably, no kindreds with renal cancer aggregation were identified by the applied criteria. However, these criteria reflect the dominant mode of transmission. A recessive mode of inheritance for renal cancer has been suggested  and in this case our criteria based on dominant mode are not applicable.
The full data set of hereditary cancer burden by location in the same group was obtained by population screening. The burden of hereditary colorectal cancer corresponds to the wide published spectrum of 1 - 13% but is lower than average estimates 5 - 6% . As expected, it exceeds the described proportion of families corresponding to Amsterdam criteria  although similar proportions have also been reported . The burden of hereditary gastric cancer is higher than estimated by Cisco et al. . Only small fraction of breast cancers corresponds to the strict criteria in contrast to frequent occurrence of relaxed (g2) criteria and hereditary ovarian cancer. As the occurrence of g1 hereditary breast cancer is rare and results from clinical screening and molecular testing do not mutually overlap, the real burden of hereditary breast-ovarian cancer is much higher than identified by g1 criteria. In contrast, the burden of familial lung cancer in our study was 2.4% that is higher than in Japan and USA (0.2 - 0.4%) by the same criteria [19, 28]. Notably, the genetically determined predisposition to lung cancer can interact with smoking [19, 29] therefore these factors cannot be considered mutually exclusive. The burden of familial pancreatic cancer in our study was 6.3% that is in line with other published results [see for reference ].
The population screening for disease-causing mutations [31, 32] becomes rational if it corresponds to certain criteria. The disease must be common and serious, with high penetrance and manageable number of predominant mutations. The test must be cheap, acceptable to whole population and an effective surveillance must be feasible . It was shown earlier that BRCA1 gene founder mutations 4153delA and 5382insC are common in Latvia [15, 33].
In order to fulfil the assumption of the economic efficacy of the screening test, only founder mutations in the BRCA1 gene were searched for and testing was offered only to the persons who reported at least one case of breast and/or ovarian cancer in the family. Part of the BRCA1 mutations may be missed by this approach. However, in this way we found 10 mutation carriers in 7 families that correspond to 2663 clinically screened persons per one mutation-bearing family. This value is comparable with data obtained by Gronwald et al.  who reported 438 mutation-bearing families corresponding to 2873 clinically screened persons per one mutation-bearing family.
The number of BRCA1 mutations exceeds the one of probands diagnosed by clinical criteria for hereditary breast-ovarian cancer, group 1. None of the BRCA1 mutation carriers was identified by group 1 clinical diagnostic criteria and 8 of them reported only isolated cases of index cancer among blood relatives. Thus, clinical criteria revealed less than half of high-risk persons. The finding of the BRCA1 mutations in individuals with no significant family history may be explained by paternal inheritance, lack of knowledge of the family cancer history or small family size. In this study, the inheritance through male was ascertained by criteria. The significance of the family size was demonstrated by higher number of blood relatives in group 1 and 2 in comparison to non-diagnostic family histories.
The BRCA mutations are known to be associated with high lifetime breast cancer risk . Although the patient group was already selected for BRCA1 testing by positive family history of breast cancer that might include also presence of breast cancer in the individual there is a trend towards higher breast cancer frequency and incidence rate in mutation carriers. The difference does not gain statistical significance due to small sample size and specific group design.
Clinical population screening by relaxed criteria can be highly recommended as it yields high number of persons to whom further surveillance should be advised. This is a practical advantage of population screening for hereditary cancer.
Population screening is a useful practical tool for the identification of persons belonging to families with high frequency of malignant tumours. Another benefit of the population screening is the possibility to identify oncologically healthy persons belonging to hereditary and familial cancer families so that appropriate surveillance can be offered.
The population screening based on clinical criteria reveals the full spectrum of hereditary cancers. Hereditary gastric cancer, familial lung cancer, hereditary non-polyposis colorectal cancer and hereditary breast and/or ovarian cancer were among the most common hereditary cancer syndromes.
Population screening discloses the age structure of hereditary cancer in the population helping to adjust the surveillance programs.
In collaboration with family doctors, the screening is technically manageable as characterised by high compliance (76.6%).
Molecular examination is an important tool in the evaluation of individual risk. It should be applied to all persons with at least single breast and/or ovarian cancer case in family if testing for founder mutations is available.
Families with established BRCA1 gene founder mutations were identified with the frequency 1:2663 clinically screened persons.
Boyle P, Ferlay J: Cancer incidence and mortality in Europe, 2004. Ann Oncol 2005, 16: 481–488. 10.1093/annonc/mdi098
Lubiński J, Korzeń M, Górski B, Cybulski C, Debniak T, Jakubowska A, Jaworska K, Wokołorczyk D, Medrek K, Matyjasik J, Huzarski T, Byrski T, Gronwald J, Masojć B, Lener M, Szymańska A, Szymańska-Pasternak J, Serrano-Fernàndez P, Piegat A, Uciński R, Domagała P, Domagała W, Chosia M, Kładny J, Górecka B, Narod S, Scott R: Genetic contribution to all cancers: the first demonstration using the model of breast cancers from Poland stratified by age at diagnosis and tumour pathology. Breast Cancer Res Treat 2009,114(1):121–126. 10.1007/s10549-008-9974-8
Daly PA: Hereditary cancer: guidelines in clinical practice - general overview. Ann Oncol 2004,15(Suppl 4):iv121–125.
Olopade OI, Pichert G: Cancer genetics in oncology practice. Ann Oncol 2001, 12: 895–908. 10.1023/A:1011176107455
Federico M, Maiorana A, Mangone L, Turchetti D, Canossi B, Cortesi L, Romagnoli R, Silingardi V: Identification of families with hereditary breast and ovarian cancer for clinical and mammographic surveillance: the Modena Study Group proposal. Breast Cancer Res Treat 1999, 55: 213–221. 10.1023/A:1006192230332
Hemminki K, Li X: Familial colorectal adenocarcinoma from the Swedish family-cancer database. Int J Cancer 2001, 94: 743–748. 10.1002/ijc.1533
Imsland AK, Eldon BJ, Arinbjarnarson S, Egilsson V, Tulinius H, Tryggvadóttir L, Arngrimsson R, Magnússon J: Genetic epidemiologic aspects of gastric cancer in Iceland. J Am Coll Surg 2002,195(2):181–186. 10.1016/S1072-7515(02)01215-2
Hemminki K, Li X: Familial and second primary pancreatic cancers: a nationwide epidemiologic study from Sweden. Int J Cancer 2003, 103: 525–530. 10.1002/ijc.10863
Hemminki K, Li X: Familial risks of cancer as a guide to gene identification and mode of inheritance. Int J Cancer 2004, 110: 291–294. 10.1002/ijc.20107
Matakidou A, Eisen T, Houlston RS: Systematic review of the relationship between family history and lung cancer risk. Br J Cancer 2005, 93: 825–833. 10.1038/sj.bjc.6602769
Eccles DM: Hereditary cancer: guidelines in clinical practice. Breast and ovarian cancer genetics. Ann Oncol 2004,15(Suppl 4):iv133-iv138.
Love RR, Evans AM, Josten DM: The accuracy of patient reports of family history of cancer. J Chronic Dis 1985, 38: 289–293. 10.1016/0021-9681(85)90074-8
Sweet KM, Bradley TL, Westman JA: Identification and referral of families at high risk for cancer susceptibility. J Clin Oncol 2002,20(2):528–537. 10.1200/JCO.20.2.528
Gronwald J, Raczynski A, Tarhoni M, Blachowski M, Huzarski T, Byrski T, Toloczko-Grabarek A, Debniak T, Cybulski C, Huzarska J, Oszurek O, Lubinski J: Population screening for cancer family syndromes in the West Pomeranian region of Poland. Hered Cancer Clin Pract 2006,4(1):56.
Gardovskis A, Irmejs A, Miklasevics E, Borosenko V, Bitina M, Melbarde-Gorkusa I, Vanags A, Kurzawski G, Suchy J, Gorski B, Gardovskis J: Clinical, molecular and geographical features of hereditary breast/ovarian cancer in Latvia. Hered Cancer Clin Pract 2005,3(2):71–76. 10.1186/1897-4287-3-2-71
Hampel H, Sweet K, Westman JA, Offit K, Eng C: Referral for cancer genetics consultation: a review and compilation of risk assessment criteria. J Med Genet 2004, 41: 81–91. 10.1136/jmg.2003.010918
Altman D, Machin D, Bryant T, Gardner S: Statistics with confidence: confidence interval and statistical guidelines. 2nd edition. Bristol: BMJ Books; 2000.
Górski B, Jakubowska A, Huzarski T, Byrski T, Gronwald J, Grzybowska E, Mackiewicz A, Stawicka M, Bebenek M, Sorokin D, Fiszer-Maliszewska Ł, Haus O, Janiszewska H, Niepsuj S, Góźdź S, Zaremba L, Posmyk M, Płuzańska M, Kilar E, Czudowska D, Waśko B, Miturski R, Kowalczyk JR, Urbański K, Szwiec M, Koc J, Debniak B, Rozmiarek A, Debniak T, Cybulski C, Kowalska E, Tołoczko-Grabarek A, Zajaczek S, Menkiszak J, Medrek K, Masojć B, Mierzejewski M, Narod SA, Lubiński J: A high proportion of founder BRCA1 mutations in Polish breast cancer families. Int J Cancer 2004,110(5):683–686. 10.1002/ijc.20162
Bailey-Wilson JE, Amos CI, Pinney SM, Petersen GM, de Andrade M, Wiest JS, Fain P, Schwartz AG, Ypu M, Franklin W, Klein C, Gazdar A, Rothschild H, Mandal D, Coons T, Slusser J, Lee J, Gaba C, Kupert E, Perez A, Zhou X, Zeng D, Liu Q, Zhang Q, Seminara D, Minna J, Anderson MW: A major lung cancer susceptibility locus maps to chromosome 6q23–35. Am J Hum Genet 2004,75(3):460–474. 10.1086/423857
Molina JR, Yang P, Cassivi SD, Schild SE, Adjei AA: Non-small cell lung cancer: epidemiology, risk factors, treatment and survivorship. Mayo Clin Proc 2008,83(5):584–594. 10.4065/83.5.584
Byrski T, Gronwald J, Huzarski T, Grzybowska E, Budryk M, Stawicka M, Mierzwa T, Szwiec M, Wisniowski R, Siolek M, Dent R, Lubinski J, Narod S: Pathologic complete response rates in young women with BRCA1-positive breast cancers after neoadjuvant chemotherapy. J Clin Oncol 2010,28(3):375–379. 10.1200/JCO.2008.20.7019
Byrski T, Huzarski T, Dent R, Gronwald J, Zuziak D, Cybulski C, Kladny J, Gorski B, Lubinski J, Narod SA: Response to neoadjuvant therapy with cisplatin in BRCA1-positive breast cancer patients. Breast Cancer Res Treat 2009,115(2):359–363. 10.1007/s10549-008-0128-9
Guillem JG, Wood WC, Moley JF, Berchuck A, Karlan BY, Mutch DG, Gagel RF, Weitzel J, Morrow M, Weber BL, Giardiello F, Rodriguez-Bigas MA, Church J, Gruber S, Offit K: ASCO/SSO review of current role of risk-reducing surgery in common hereditary cancer syndromes. Ann Surg Oncol 2006, 13: 1296–1321. 10.1245/s10434-006-9036-6
Trimbath JD, Giardiello FM: Review article: genetic testing and counselling for hereditary colorectal cancer. Aliment Pharmacol Ther 2002, 16: 1843–1857. 10.1046/j.1365-2036.2002.01357.x
Olsson L, Lindblom A: Family history of colorectal cancer in a Sweden county. Fam Cancer 2002,2(2):87–93. 10.1023/A:1025734200635
Raedle J, Schaffner M, Esser N, Sahm S, Trojan J, Kriener S, Brieger A, Nier H, Bockhorn H, Berg PL, Frick B, Schäfer D, Zeuzem S: Frequency of the Amsterdam Criteria in a regional German cohort of patients with colorectal cancer. Z Gastroenterol 2002,40(8):561–568. 10.1055/s-2002-33419
Cisco RM, Ford JM, Norton JA: Hereditary diffuse gastric cancer: implications of genetic testing for screening and prophylactic surgery. Cancer 2008,113(Suppl 7):1850–1856. 10.1002/cncr.23650
Tomizawa Y, Adachi J, Kohno T, Yamaguchi N, Saito R, Yokota J: Identification and characterization of families with aggregation of lung cancer. Jpn J Clin Oncol 1998,28(3):192–195. 10.1093/jjco/28.3.192
Bermejo JL, Hemminki K: Familial lung cancer and aggregation of smoking habits: a simulation of the effect of shared environmental factors on the familial risk of cancer. Cancer Epidemiol Biomarkers Prev 2005,14(7):1738–1740. 10.1158/1055-9965.EPI-05-0201
Windsor JA: An update on familial pancreatic cancer and the management of asymptomatic relatives. HPB 2007, 9: 4–7. 10.1080/13651820600985325
Grody WW: Molecular genetic risk screening. Annu Rev Med 2003, 54: 473–490. 10.1146/annurev.med.54.101601.152127
Guttmacher AE, Collins FS: Population screening in the age of genomic medicine. NEJM 2003,348(1):50–58. 10.1056/NEJMra013182
Tikhomirova L, Sinicka O, Smite D, Eglitis J, Hodgson SV, Stengrevics A: High prevalence of two BRCA1 mutations, 4154delA and 5382insC, in Latvia. Fam Cancer 2005, 4: 77–84. 10.1007/s10689-004-2758-3
The investigation was carried out within the frames of the project "The development of hereditary cancer prophylaxis in Estonia and Latvia" co-financed by European Union Interreg IIIB Neighbourhood programme. The research was supported also by European Social Fund, agreement Nr. 2009/0230/1DP/22.214.171.124.0/09/APIA/VIAA/070. AV is supported by ESF fellowship, project Nr. 2009/0147/1DP/126.96.36.199.2/09/IPIA/VIAA/009
The authors declare that they have no competing interests.
AV participated in the study design and clinical consultations, performed statistical analysis and wrote the manuscript. IS helped to draft the manuscript. AG and VB participated in clinical consultations. AA participated in the analysis and interpretation of data. UT supervised the statistical analysis. GT helped to draft the manuscript. EM performed the molecular examinations. JG designed and coordinated the study and helped to draft the manuscript. All authors read and approved the final manuscript.
About this article
Cite this article
Vanags, A., Štrumfa, I., Gardovskis, A. et al. Population screening for hereditary and familial cancer syndromes in Valka district of Latvia. Hered Cancer Clin Pract 8, 8 (2010). https://doi.org/10.1186/1897-4287-8-8
- Founder Mutation
- Hereditary Cancer
- Population Screening
- Familial Cancer
- Blood Relative