Table 1 Diagnostic criteria used in the population screening for hereditary cancer.

Hereditary non-polyposis colorectal cancer, group 1^a (HNPCC/g1)

Amsterdam II criteria [15]

HNPCC, group 2 (HNPCC/g2)

At least 2 first degree relatives with HNPCC associated cancer (colorectal, endometrial, small bowel, ureteric, renal pelvis) and at least one cancer diagnosed before age 50

Familial colorectal cancer, group 2 (FCC/g2)

Colorectal cancer in at least two first or second degree relatives. HNPCC and familial adenomatous polyposis should be excluded

Hereditary breast cancer, group 1 (HBC/g1)

At least 3 breast cancer patients in family and one of those patients is first degree relative to other two or second degree relative through male

Hereditary breast cancer, variety 1, group 2 (HBC1/g2)

At least one of the following criteria:

1) Breast cancer diagnosed under the age of 40;

2) Medullary or atypical medullary breast cancer;

3) Male breast cancer;

4) Bilateral breast cancer, one of them diagnosed under the age of 50.

Hereditary breast cancer, variety 2, group 2 (HBC2/g2)

Two breast cancer cases among first degree relatives (or second degree through male)

Hereditary ovarian cancer, group 1 (HOC/g1)

At least 3 ovarian cancer cases in family and one of those patients is first degree relative to other two or second degree relative through male

Hereditary ovarian cancer, group 2 (HOC/g2)

Two ovarian cancer cases among first degree relatives

Hereditary breast-ovarian cancer, group 1 (HBOC/g1)

At least 3 breast or ovarian cancer patients in family at any age and one of those patients is first degree relative to other two or second degree relative through male

Hereditary breast-ovarian cancer, variety 1, group 2 (HBOC1/g2)

Breast and ovarian cancer in the same individual at any age

Hereditary breast/ovarian cancer, variety 2, group 2 (HBOC2/g2)

One breast cancer diagnosed under the age of 50 and one ovarian cancer diagnosed at any age among first degree relatives or second degree relatives through male

Hereditary endometrial cancer, group 1 (HEC/g1)

At least 3 first degree relatives with endometrial cancer and at least one of them diagnosed before age of 50

Hereditary endometrial cancer, group 2 (HEC/g2)

Two first degree relatives with endometrial cancer and at least one of them diagnosed before age of 50

Familial endometrial cancer, group 1 (FEC/g1)

At least 3 first degree relatives with endometrial cancer. HEC/g1 should be excluded

Familial endometrial cancer, variety 1, group 2 (FEC1/g2)

At least 2 first degree relatives with endometrial cancer. HEC/g2 should be excluded

Familial endometrial cancer, variety 2, group 2 (FEC2/g2)

At least 2 second degree relatives with endometrial cancer

Familial lung cancer, group 1 (FLC/g1)

At least 3 first degree relatives with lung cancer

Familial lung cancer, group 2 (FLC/g2)

Two first degree relatives with lung cancer

Hereditary gastric cancer, group 1 (HGC/g1)

At least 3 first degree relatives with gastric cancer

Hereditary gastric cancer, group 2 (HGC/g2)

Two first degree relatives with gastric cancer

Hereditary prostate cancer, group 1 (HPC/g1)

At least 3 blood relatives with prostate cancer at any age or 2 blood relatives with prostate cancer diagnosed before age of 55 in both of them

Hereditary prostate cancer, group 2 (HPC/g2)

Two blood relatives with prostate cancer at any age or a case of prostate cancer diagnosed before age of 55

Familial brain tumour, group 1 (FBT/g1)

At least 3 first degree relatives with brain tumour

Familial brain tumour, group 2 (FBT/g2)

Two first degree relatives with brain tumour

Familial malignant haematological tumour, group 1 (FHemT/g1)

At least 3 first degree relatives with malignant haematological tumour

Familial malignant haematological tumour, group 2 (FHemT/g2)

Two first degree relatives with malignant haematological tumour

Familial pancreatic tumour, group 1 (FPan/g1)

At least 2 first degree relatives with pancreatic tumour or melanoma

Familial urinary bladder cancer, group 1 (FBlaC/g1)

At least 3 first degree relatives with urinary bladder cancer

Familial urinary bladder cancer, group 2 (FBlaC/g2)

Two first degree relatives with urinary bladder cancer

Other familial cancer syndromes

At least 3 first degree relatives with concordant cancer