Racial differences in a high-risk colorectal cancer referral population: a single-center experience
© Gulden et al; licensee BioMed Central Ltd. 2011
Published: 10 March 2011
Multiple studies have shown that colorectal cancer (CRC) disparities exist between African Americans and Caucasians. African Americans have higher CRC incidence and mortality than Caucasians [1, 2]. Furthermore, African Americans present with more advanced CRC  and at younger ages . However, little is known about the impact of hereditary CRC syndromes in African Americans on these disparities. In the University of Chicago Cancer Risk Clinic, we see a diverse referral population for evaluation of hereditary syndromes based on personal or family history of CRC. We sought to compare clinical characteristics of our African American and Caucasian patients to determine if differences exist in a high-risk CRC referral population.
We retrospectively collected data on self-reported African American and Caucasian individuals who were referred for a personal or family history of CRC from 1992-2010. Available clinical characteristics including number of individuals, number of families (probands with family members who followed-up in our clinic), personal or family history of CRC, age at cancer onset, and number of individuals who underwent genetic testing for APC or mismatch repair genes were collected. Pedigrees were reviewed to determine Revised Bethesda, Amsterdam II and PREMM1,2 scores. Statistical analysis included Student’s t-test for continuous variables and Pearson’s chi-square for categorical variables. Comparison of independent proportions was done using z-ratios.
Clinical characteristics of individuals referred for personal and/or family history of CRC by race
Personal and/or family history of CRC
Total number of individuals
Total number families (% of total individuals)
Median # CRC affected family members (range)
Average number CRC affected family members < 50 years
Number with polyps (%)
Genetic testing (%)
Personal History of CRC
Total number (% of total)
Age years (mean)
Revised Bethesda + (%)
Amsterdam II + (%)
Genetic testing (%)
Despite many similarities between our high-risk CRC populations, there exists a difference in the number of family members of African American probands seen in our clinic and the number of African Americans who had genetic testing when compared to Caucasians. Less genetic testing may mean African American mutation carriers are not being identified. This can significantly impact appropriate cancer screening recommendations and knowledge about hereditary CRC syndromes in this population. Future collaborative studies are needed to address why these differences may exist.
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