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  1. Content type: Research

    Cyclin-dependent kinase 4 (CDK4) together with its regulatory subunit cyclin D1, governs cell cycle progression through G1 phase. Cyclin-dependent kinase inhibitors, including p16INK4A in turn regulate CDK4. In p...

    Authors: Maimoona Sabir, Ruqia Mehmood Baig, Ishrat Mahjabeen and Mahmood Akhtar Kayani

    Citation: Hereditary Cancer in Clinical Practice 2012 10:11

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  2. Content type: Research

    The molecular etiology of thyroid carcinoma (TC) and other thyroid diseases which may present malignant precursor lesions is not fully explored yet. The purpose of this study was to estimate frequency, type an...

    Authors: Hans-Juergen Schulten, Sherine Salama, Zuhoor Al-Mansouri, Reem Alotibi, Khalid Al-Ghamdi, Osman Abdel Al-Hamour, Hassan Sayadi, Hosam Al-Aradati, Adel Al-Johari, Etimad Huwait, Mamdooh Gari, Mohammed Hussain Al-Qahtani and Jaudah Al-Maghrabi

    Citation: Hereditary Cancer in Clinical Practice 2012 10:10

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  3. Content type: Review

    With the discovery that the hereditary cancer susceptibility disease Lynch syndrome (LS) is caused by deleterious germline mutations in the DNA mismatch repair (MMR) genes nearly 20 years ago, genetic testing ...

    Authors: Christopher D Heinen and LJ Rasmussen

    Citation: Hereditary Cancer in Clinical Practice 2012 10:9

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  4. Content type: Research

    Pancreatic cancer (PC) is considered the most lethal cancer and approximately 10% of PC is hereditary. The purpose of the study was to assess attitudes of at-risk family members with two or more relatives affe...

    Authors: Carmen Radecki Breitkopf, Pamela S Sinicrope, Kari G Rabe, Tabetha A Brockman, Christi A Patten, Robert R McWilliams, Shawna Ehlers and Gloria M Petersen

    Citation: Hereditary Cancer in Clinical Practice 2012 10:8

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  5. Content type: Research

    Breast cancer is the most prevalent malignancy in women in Western countries, currently accounting for one third of all female cancers. Familial aggregation is thought to account for 5–10 % of all BC cases, an...

    Authors: Nadine Jalkh, Jinane Nassar-Slaba, Eliane Chouery, Nabiha Salem, Nancy Uhrchammer, Lisa Golmard, Domique Stoppa-Lyonnet, Yves-Jean Bignon and André Mégarbané

    Citation: Hereditary Cancer in Clinical Practice 2012 10:7

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  6. Content type: Research

    A growing number of individuals are diagnosed with hereditary cancer. Though increased levels of anxiety and depression have been demonstrated around the time of genetic counselling, most individuals handle li...

    Authors: Katarina Bartuma, Mef Nilbert and Christina Carlsson

    Citation: Hereditary Cancer in Clinical Practice 2012 10:6

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  7. Content type: Meeting abstract

    Authors: Urszula Teodorczyk, Cezary Cybulski, Anna Jakubowska, Teresa Starzyńska, Małgorzata Ławniczak, Paweł Domagała, Katarzyna Ferenc, Krzysztof Marlicz, Zbigniew Banaszkiewicz, Rafał Wiśniowski and Jan Lubiński

    Citation: Hereditary Cancer in Clinical Practice 2012 10(Suppl 3):A22

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    This article is part of a Supplement: Volume 10 Supplement 3

  8. Content type: Meeting abstract

    Authors: Grzegorz Sukiennicki, Magdalena Muszyńska, Tomasz Huzarski, Jacek Gronwald, Cezary Cybulski, Tadeusz Dębniak, Aleksandra Tołoczko-Grabarek, Oleg Ashuryk, Anna Jakubowska, Antoni Morawski and Jan Lubiński

    Citation: Hereditary Cancer in Clinical Practice 2012 10(Suppl 3):A21

    Published on:

    This article is part of a Supplement: Volume 10 Supplement 3

  9. Content type: Meeting abstract

    Authors: Magdalena Muszyńska, Grzegorz Sukiennicki, Tomasz Huzarski, Jacek Gronwald, Cezary Cybulski, Tadeusz Dębniak, Aleksandra Tołoczko-Grabarek, Oleg Ashuryk, Anna Jakubowska, Antoni Morawski and Jan Lubiński

    Citation: Hereditary Cancer in Clinical Practice 2012 10(Suppl 3):A17

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    This article is part of a Supplement: Volume 10 Supplement 3

  10. Content type: Meeting abstract

    Authors: Katarzyna Jaworska, Anna Jakubowska, Katarzyna Durda, Tomasz Huzarski, Pablo Serrano-Fernandez, Grzegorz Sukiennicki, Magdalena Muszyńska, Tomasz Byrski, Jacek Gronwald, Satish Gupta, K Kaczmarek and Jan Lubiński

    Citation: Hereditary Cancer in Clinical Practice 2012 10(Suppl 3):A8

    Published on:

    This article is part of a Supplement: Volume 10 Supplement 3

  11. Content type: Meeting abstract

    Authors: Katrzyna Jaworska, Satish Gupta, Katarzyna Durda, Magdalena Muszynska, Grzegorz Sukiennicki, Elżbieta Jaworowska, Tomasz Grodzki, Mieczysław Sulikowski, Piotr Woloszczyk, Janusz Wójcik, Jakub Lubiński, Cezary Cybulski, Tadeusz Dębniak, Marcin Lener, Steven A Narod, Ping Sun…

    Citation: Hereditary Cancer in Clinical Practice 2012 10(Suppl 3):A7

    Published on:

    This article is part of a Supplement: Volume 10 Supplement 3

  12. Content type: Meeting abstract

    Authors: Katarzyna Durda, Anna Jakubowska, Krzysztof Kąklewski, Katarzyna Jaworska, Satish Gupta, Tomasz Byrski, Tomasz Huzarski, Jacek Gronwald, Cezary Cybulski, Tadeusz Dębniak, Aleksandra Tołoczko, Oleg Ashuryk and Jan Lubiński

    Citation: Hereditary Cancer in Clinical Practice 2012 10(Suppl 3):A6

    Published on:

    This article is part of a Supplement: Volume 10 Supplement 3

  13. Content type: Case report

    We would like to present a patient with a classical phenotype of a rare disorder - Cowden syndrome, its diagnostics and management challenges. A breast surgeon has to be aware of this rare condition when treat...

    Authors: Inga Melbārde-Gorkuša, Arvīds Irmejs, Dace Bērziņa, Ilze Štrumfa, Arnis Āboliņš, Andris Gardovskis, Signe Subatniece, Genādijs Trofimovičs, Jānis Gardovskis and Edvīns Miklaševičs

    Citation: Hereditary Cancer in Clinical Practice 2012 10:5

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  14. Content type: Meeting abstract

    Authors: S Sawyer, S Boyle, MA Young, S Kovalenko, R Doherty, J McKinley, K Alsop, M Rehfisch, S Macaskill, A Ha, V Beshay, G Lindeman, M Harris, S Fox, G Mitchell and P James

    Citation: Hereditary Cancer in Clinical Practice 2012 10(Suppl 2):A89

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    This article is part of a Supplement: Volume 10 Supplement 2

  15. Content type: Meeting abstract

    Authors: KA Phillips, RL Milne, MA Rookus, D Goldgar, M Friedlander, SA McLachlan, S Buys, AC Antoniou, K Birch, MB Terry, DF Easton, P Weideman, M Daly, N Andrieu, EM John, MJ Hooning…

    Citation: Hereditary Cancer in Clinical Practice 2012 10(Suppl 2):A11

    Published on:

    This article is part of a Supplement: Volume 10 Supplement 2

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