Volume 13 Supplement 2

Meeting abstracts from the Annual Conference on Hereditary Cancers 2014

Open Access

Pathological complete response to neoadjuvant cisplatin in BRCA1-positive breast cancer patients

  • Tomasz Byrski1,
  • Tomasz Huzarski2,
  • Rebecca Dent3,
  • Elzbieta Marczyk4,
  • Marek Jasiowka4,
  • Jacek Gronwald2,
  • Jerzy Jakubowicz4,
  • Cezary Cybulski2,
  • Rafal Wisniowski5,
  • Dariusz Godlewski6,
  • Jan Lubinski2 and
  • Steven A Narod7
Hereditary Cancer in Clinical Practice201513(Suppl 2):A8

https://doi.org/10.1186/1897-4287-13-S2-A8

Published: 26 November 2015

Purpose

To estimate the frequency of pathologic complete response (pCR) after neoadjuvant treatment with cisplatin chemotherapy in women with breast cancer and who are BRCA1 mutation carriers.

Patients and Methods

107 women with BRCA1 mutation and affected with breast cancer, who presented with stage I to III breast cancer between December 2006 and June 2014 received treatment with cisplatin 75 mg/m2 every three weeks for four cycles, followed by mastectomy and conventional chemotherapy (AC). Information on clinical stage, grade, hormone receptor status and HER2 status was collected prior to treatment. Review of surgical samples was done in order to determine the pathologic complete response.

Results

107 patients were included in the study. 93 patients were treated for first primary breast cancer and 14 patients had previously received treatment for a prior cancer. A pathologic complete response was observed in 65 of the 107 patients (61%).

Conclusions

In a high proportion of patients with BRCA1-associated breast cancer platinum-based chemotherapy is an effective method of treatment.

Authors’ Affiliations

(1)
Department of Oncology, Pomeranian Medical University. International Hereditary Cancer Center
(2)
Department of Genetics and Pathology, Pomeranian Medical University. International Hereditary Cancer Center
(3)
Sunnybrook Odette Cancer Center
(4)
Oncology Institute
(5)
Regional Oncology Center
(6)
Center for Epidemiology and Prevention
(7)
Women's College Research Institute

Copyright

© Byrski et al. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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