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  1. Several studies have demonstrated that familial breast cancers associated with BRCA1 or BRCA2 germline mutations differ in their morphological and immunohistochemical characteristics. Cancers associated with BRCA...

    Authors: Emiliano Honrado, Javier Benítez and José Palacios
    Citation: Hereditary Cancer in Clinical Practice 2004 2:131
  2. Prostate cancer is the most common cancer in men and the second highest cause of cancer-related mortality in the U.K. A genetic component in predisposition to prostate cancer has been recognized for decades. O...

    Authors: Sashi Kommu, Stephen Edwards and Rosalind Eeles
    Citation: Hereditary Cancer in Clinical Practice 2004 2:111
  3. Approximately 3-15% of all malignant melanomas (MM) are familial cases. MM is a highly heterogeneous tumour type from a genetic perspective. Pedigrees with disease confined to a single generation of siblings o...

    Authors: Tadeusz Dębniak
    Citation: Hereditary Cancer in Clinical Practice 2004 2:123
  4. We report three Dutch families with familial clustering of (pre)neoplastic cervical disease, review the literature on familial risks of cervical intraepithelial neoplasia (CIN) and cervical cancer, and discuss...

    Authors: Margreet Zoodsma, Rolf H Sijmons, Elisabeth GE de Vries and Ate GJ van der Zee
    Citation: Hereditary Cancer in Clinical Practice 2004 2:99
  5. Approximately 10% of gastric cancer cases show familial clustering but only 1-3% of gastric carcinomas arise as a result of inherited gastric cancer predisposition syndromes. Direct proof that Hereditary Gastr...

    Authors: Carla Oliveira, Gianpaolo Suriano, Paulo Ferreira, Paulo Canedo, Pardeep Kaurah, Rita Mateus, Ana Ferreira, António C Ferreira, Maria José Oliveira, Céu Figueiredo, Fátima Carneiro, Gisela Keller, David Huntsman, José Carlos Machado and Raquel Seruca
    Citation: Hereditary Cancer in Clinical Practice 2004 2:51
  6. Familial adenomatous polyposis (FAP) is characterized by the presence of hundreds to thousands of adenomas that carpet the entire colon and rectum. Nonsense and frameshift mutations in the adenomatous polyposi...

    Authors: Rodney J Scott, Renee Crooks, Lindy Rose, John Attia, Ammarin Thakkinstian, Lesley Thomas, Allan D Spigelman and Cliff J Meldrum
    Citation: Hereditary Cancer in Clinical Practice 2004 2:81
  7. To determine which individuals with colorectal cancer (CRC) were interested in knowing the results of their tumour microsatellite instability (MSI) and immunohistochemistry (IHC) testing. We were also interest...

    Authors: Noralane M Lindor, Jeff Sloan, Richard Goldberg, Deborah Bowen, Sandra Nigon, Amber Roche, Gloria Petersen, Stephen N Thibodeau, Laurence Burgart, Olga Leontovich and Bruce W Morlan
    Citation: Hereditary Cancer in Clinical Practice 2004 2:69
  8. Gastric cancer is the second most frequently diagnosed malignancy worldwide and therefore represents a significant healthcare burden. Environmental and genetic factors are involved in the development of gastri...

    Authors: Beata Gawdis-Wojnarska, Marek Brzosko, Jacek Fliciński, Krzysztof Marlicz, Teresa Starzyńska, Rodney J Scott and Jan Lubiński
    Citation: Hereditary Cancer in Clinical Practice 2004 2:65
  9. Central nervous system hemangioblastomas (cHAB) are rare tumours which most commonly arise in the cerebellum. Most tumours are sporadic, but as many as one third of cHABs occur in the course of the hereditary ...

    Authors: Cezary Cybulski, Joanna Matyjasik, Marianna Soroka, Janusz Szymaś, Bohdan Górski, Tadeusz Dębniak, Anna Jakubowska, Andrzej Bernaczyk, Lech Zimnoch, Grażyna Bierzyńska-Macyszyn, Tomasz Trojanowski, Teresa Wierzba-Bobrowicz, Edmund Prudlak, Alicja Markowska-Wojciechowska, Przemysław Nowacki, Andrzej Roszkiewicz…
    Citation: Hereditary Cancer in Clinical Practice 2004 2:93
  10. There is much debate in the literature about familial predispositions to breast and bowel cancers yet little evidence is forthcoming to suggest that there are susceptibility genes that can account for such kin...

    Authors: Rodney J Scott and Katie A Ashton
    Citation: Hereditary Cancer in Clinical Practice 2004 2:25
  11. When BRCA1/2 genetic susceptibility testing was introduced in the clinic in the mid-nineties, the "Huntington protocol" was used in the counselling of individuals applying for genetic testing. This protocol inclu...

    Authors: Iris van Oostrom and Aad Tibben
    Citation: Hereditary Cancer in Clinical Practice 2004 2:19
  12. This paper highlights the need for carriers to be followed up by health professionals who understand the complexities of the BRCA syndrome. A BRCA carrier clinic has been established in London and regular follow ...

    Authors: Audrey Ardern-Jones and Rosalind Eeles
    Citation: Hereditary Cancer in Clinical Practice 2004 2:77
  13. The aim of the study is to evaluate the incidence and phenotype - genotype characteristics of hereditary colorectal cancer syndromes in Latvia in order to develop the basis of clinical management for patients ...

    Authors: Arvids Irmejs, Andris Gardovskis, Viktors Borosenko, Marianna Bitina, Diana Aigare, Grzegorz Kurzawski, Janina Suchy, Bohdan Górski and Janis Gardovskis
    Citation: Hereditary Cancer in Clinical Practice 2003 1:49
  14. Denaturing high performance liquid chromatography is a relatively new method by which heteroduplex structures formed during the PCR amplification of heterozygote samples can be rapidly identified. The use of t...

    Authors: Cliff J. Meldrum, Mary McPhillips, Renee Crooks, Lesley Thomas, Ted Edkins, Rohanna Creegan, Ewan Miller, Michael Agrez and Rodney J. Scott
    Citation: Hereditary Cancer in Clinical Practice 2003 1:39
  15. The criteria for the diagnosis of HNPCC established by the ICG-HNPCC are very restrictive as they do not allow for the diagnosis of a large number of "suspected HNPCC" cases - these are families which do no fu...

    Authors: Józef Kładny, Gabriela Möslein, Torben Myrhøj, Grzegorz Kurzawski, Anna Jakubowska, Tadeusz Dębniak, Wojciech Petriczko, Michał Kozłowski, Tariq Al-Amawi, Marek Brzosko, Jacek Fliciński, Arkadiusz Jawień, Zbigniew Banaszkiewicz, Piotr Rychter and Jan Lubiński
    Citation: Hereditary Cancer in Clinical Practice 2003 1:34
  16. In addition to a relatively small number of well known hereditary cancer syndromes, hundreds of presumed or proven hereditary disorders have been observed to manifest cancer as a characteristic feature or as a...

    Authors: Rolf H. Sijmons and Gerard T.N. Burger
    Citation: Hereditary Cancer in Clinical Practice 2003 1:31
  17. HNPCC (Lynch syndrome) is the most common form of hereditary colorectal cancer (CRC), wherein it accounts for between 2-7 percent of the total CRC burden. When considering the large number of extracolonic canc...

    Authors: Henry T. Lynch, Jane F. Lynch, Trudy G. Shaw and Jan Lubiński
    Citation: Hereditary Cancer in Clinical Practice 2003 1:7

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