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  1. Whereas HER2 amplification is a well-known phenomenon in breast tumours, its frequency and clinical importance in ovarian cancer have not been established. The aim of the study was to compare the frequency of HER...

    Authors: Izabela Brożek, Iwona Kardaś, Karolina Ochman, Jarosław Dębniak, Maciej Stukan, Magdalena Ratajska, Lucyna Morzuch, Janusz Emerich and Janusz Limon

    Citation: Hereditary Cancer in Clinical Practice 2006 4:39

    Content type: Research

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  2. The majority of hereditary breast and ovarian cancers can be accounted for by germline mutations in the BRCA1 and BRCA2 genes. Genetic counselling and testing in high-risk patients in the Czech Republic began ...

    Authors: Lenka Foretova, Katarina Petrakova, Marketa Palacova, Renata Kalabova, Marie Navratilova, Miroslava Lukesova, Petra Vasickova, Eva Machackova, Zdenek Kleibl and Petr Pohlreich

    Citation: Hereditary Cancer in Clinical Practice 2006 4:3

    Content type: Research

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  3. Paragangliomas are rare tumours of the autonomic nervous system and occur in sporadic and hereditary forms. They are usually benign and have a low mortality. However, they cause significant morbidity related t...

    Authors: CJM Lips, EGWM Lentjes, JWM Höppener, RB van der Luijt and FL Moll

    Citation: Hereditary Cancer in Clinical Practice 2006 4:169

    Content type: Review

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  4. The BRCA1 4153delA allele is frequently referred to as the Russian founder mutation, as it was initially detected in several cancer families from Moscow. Our earlier studies have demonstrated 1% occurrence of ...

    Authors: Nadezhda Yu Krylova, Oksana S Lobeiko, Anna P Sokolenko, Aglaya G Iyevleva, Maxim E Rozanov, Natalia V Mitiushkina, Madina M Gergova, Tatiana V Porhanova, Adel F Urmancheyeva, Sergey Ya Maximov, Alexandr V Togo and Evgeny N Imyanitov

    Citation: Hereditary Cancer in Clinical Practice 2006 4:193

    Content type: Research

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    The Erratum to this article has been published in Hereditary Cancer in Clinical Practice 2007 5:56

  5. This study was undertaken to determine: 1) Type and prevalence of founder mutations BRCA1 and BRCA2 genes in Polish families with strong aggregation of breast and/or ovarian cancer. 2) Risk of breast and/or ovari...

    Authors: Bohdan Górski

    Citation: Hereditary Cancer in Clinical Practice 2006 4:142

    Content type: Research

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  6. A family is reported in which three male siblings of Asian descent developed non-Hodgkin's lymphoma (NHL). Case 1 was diagnosed with indolent follicular lymphoma stage IIIA at age 45. Case 2 presented with lar...

    Authors: Sandra S.C.M. Loves, Lieuwe de Haan and Simon M.G.J. Daenen

    Citation: Hereditary Cancer in Clinical Practice 2006 4:136

    Content type: Case report

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  7. MTC is a rare neuroendocrine thyroid tumour accounting for 3% to 10% of all thyroid malignancies. It can occur in a sporadic and a hereditary clinical setting. Hereditary MTC may either occur alone (familial M...

    Authors: Jan Willem de Groot, Thera P. Links, Robert M.W. Hofstra and John T.M. Plukker

    Citation: Hereditary Cancer in Clinical Practice 2006 4:115

    Content type: Review

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  8. Xeroderma pigmentosum (XP) is a rare recessive disorder that is characterized by extreme sensitivity to UV light. UV light exposure results in the formation of DNA damage such as cyclobutane dimers and (6-4) p...

    Authors: Nikola A. Bowden, Paul A. Tooney and Rodney J. Scott

    Citation: Hereditary Cancer in Clinical Practice 2006 4:103

    Content type: Research

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  9. Catechol-O-methyltransferase (COMT) is vital for the conjugation of catechol estrogens that are produced during oestrogen metabolism. The efficiency of this process varies due to a polymorphism in COMT, which ...

    Authors: Katie A. Ashton, Cliff J. Meldrum, Mary L. McPhillips, Janina Suchy, Grzegorz Kurzawski, Jan Lubinski and Rodney J. Scott

    Citation: Hereditary Cancer in Clinical Practice 2006 4:94

    Content type: Research

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  10. Recently, carriers of biallelic mutations in the base excision repair gene MUTYH, have been demonstrated to have a predisposition for multiple adenomas and colorectal cancer. Still, many questions remain unanswer...

    Authors: Astrid Stormorken, Karen-Marie Heintz, Per Arne Andresen, Eivind Hovig and Pål Møller

    Citation: Hereditary Cancer in Clinical Practice 2006 4:90

    Content type: Research

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  11. Childhood adrenocortical tumour (ACT) is not a common disease, but in southern Brazil the prevalence is 15 times higher than in other parts of the world. One hundred and thirty-seven patients have been identif...

    Authors: Rosana Marques-Pereira, Luiz DeLacerda, Hadriano M Lacerda, Edson Michalkiewicz, Fabiano Sandrini and Romolo Sandrini

    Citation: Hereditary Cancer in Clinical Practice 2006 4:81

    Content type: Review

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  12. Global analysis of gene expression by DNA microarrays is nowadays a widely used tool, especially relevant for cancer research. It helps the understanding of complex biology of cancer tissue, allows identificat...

    Authors: Volha Dudaladava, Michał Jarząb, Ewa Stobiecka, Ewa Chmielik, Krzysztof Simek, Tomasz Huzarski, Jan Lubiński, Jolanta Pamuła, Wioletta Pękala, Ewa Grzybowska and Katarzyna Lisowska

    Citation: Hereditary Cancer in Clinical Practice 2006 4:28

    Content type: Research

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  13. Authors: Tadeusz Dębniak, Cezary Cybulski, Grzegorz Kurzawski, Bohdan Górski, Tomasz Huzarski, Tomasz Byrski, Jacek Gronwald, Janina Suchy, Bartłomiej Masojć, Marek Mierzejewski, Marcin Lener, Urszula Teodorczyk, Krzysztof Mędrek, Elżbieta Złowocka, Ewa Grabowska-Kłujszo, Katarzyna Nej-Wołosiak…

    Citation: Hereditary Cancer in Clinical Practice 2006 4:52

    Content type: Short report

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  14. It has not been established whether CHEK2 and NOD2 variants are present in Latvia and whether inherited variation in these genes influences cancer risk in this population.

    Authors: Arvids Irmejs, Edvins Miklasevics, Viktors Boroschenko, Andris Gardovskis, Andrejs Vanags, Inga Melbarde-Gorkusa, Marianna Bitina, Janina Suchy and Janis Gardovskis

    Citation: Hereditary Cancer in Clinical Practice 2006 4:48

    Content type: Research

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  15. Familial Adenomatous Polyposis (FAP) is an inheritable predisposition for the occurrence of numerous polyps in the large intestine. In about 50% of all patients, the occurrence of the disease is conditioned by...

    Authors: Marzena Skrzypczak, Marta Podralska, Wolfram Heinritz, Ursula G Froster, Daniel Lipiński, Ryszard Słomski and Andrzej Pławski

    Citation: Hereditary Cancer in Clinical Practice 2006 4:43

    Content type: Research

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  16. The 5' region of BRCA1 contains multiple regulatory sequences flanking the two alternative promoters α and β and two alternative, non-coding exons, 1a and 1b. Aberrations within the 5' region BRCA1 (encompassing ...

    Authors: Jolanta Pamuła, Małgorzata Krześniak, Helena Zientek, Wioletta Pękala, Marek Rusin and Ewa Grzybowska

    Citation: Hereditary Cancer in Clinical Practice 2006 4:20

    Content type: Research

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  17. The frameshift NOD2 gene mutation 3020insC is predominantly associated with Crohn's disease, but predisposes to many types of common cancers as well. We studied the frequency of this mutant NOD2 allele in 148 bre...

    Authors: Hanna Janiszewska, Olga Haus, Anna Lauda-Świeciak, Aneta Bąk, Tomasz Mierzwa, Jan Sir and Ryszard Laskowski

    Citation: Hereditary Cancer in Clinical Practice 2006 4:15

    Content type: Research

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  18. A germline mutation in the Von-Hippel Lindau (VHL) gene predisposes carriers to development of abundantly vascularised tumours in the retina, cerebellum, spine, kidney, adrenal gland and pancreas. Most VHL pat...

    Authors: Frederik J Hes, Jo WM Höppener, Rob B van der Luijt and Cornelis JM Lips

    Citation: Hereditary Cancer in Clinical Practice 2005 3:171

    Content type: Review

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  19. Hereditary cancers are thought to account for around 5% of cancers, particularly breast/ovarian and colorectal cancers. In India there is a paucity of data on hereditary cancers and the mutations in some of th...

    Authors: T Rajkumar, N Soumittra, E Vidubala, V Sridevi, V Mahajan, SG Ramanan and S Vijaya

    Citation: Hereditary Cancer in Clinical Practice 2005 3:165

    Content type: Short report

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  20. The purpose of this article is to review basic research as well as clinical studies on Chinese hereditary colorectal cancer. Hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) accounts for 2.2% ...

    Authors: Zheng Shu, Huang Yanqin and Yuan Ying

    Citation: Hereditary Cancer in Clinical Practice 2005 3:155

    Content type: Review

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  21. Hereditary non polyposis colorectal cancer (HNPCC) is characterized by the presence of early onset colorectal cancer and other epithelial malignancies. The genetic basis of HNPCC is a deficiency in DNA mismatc...

    Authors: Mary McPhillips, Cliff J Meldrum, Rhona Creegan, Edward Edkins and Rodney J Scott

    Citation: Hereditary Cancer in Clinical Practice 2005 3:43

    Content type: Research

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  22. In writing the letter to readers of our journal three months ago I was asking about opinions concerning the use of hormone replacement therapy (HRT) in BRCA1/2 carriers after prophylactic adnexectomy, because ...

    Authors: Jan Lubiński

    Citation: Hereditary Cancer in Clinical Practice 2005 3:87

    Content type: Letter to the editor

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  23. Renal clear cell carcinomas represent about 3% of all visceral cancers and account for approximately 85% of renal cancers in adults. Environmental and genetic factors are involved in the development of renal c...

    Authors: Aleksandra Tołoczko-Grabarek, Andrzej Sikorski, Marek Brzosko and Jan Lubiński

    Citation: Hereditary Cancer in Clinical Practice 2005 3:129

    Content type: Research

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  24. Recently mutations in the MYH gene have been associated with a milder form of adenomatous polyposis which is characterized by a variable level of colonic polyps ranging from a few to several hundred. In the conte...

    Authors: Katie A. Ashton, Cliff J. Meldrum, Mary L. McPhillips, Carla F. Kairupan and Rodney J. Scott

    Citation: Hereditary Cancer in Clinical Practice 2005 3:65

    Content type: Research

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  25. The aim of the study is to evaluate the incidence and phenotype-genotype characteristics of hereditary breast and ovarian cancer syndromes in Latvia in order to develop the basis of clinical management for pat...

    Authors: Andris Gardovskis, Arvids Irmejs, Edvins Miklasevics, Viktors Borosenko, Marianna Bitina, Inga Melbarde-Gorkusa, Andrejs Vanags, Grzegorz Kurzawski, Janina Suchy, Bohdan Górski and Janis Gardovskis

    Citation: Hereditary Cancer in Clinical Practice 2005 3:71

    Content type: Research

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  26. To compare the presentation of invasive breast cancer in BRCA1 and BRCA2 mutation carriers with and without prior bilateral oophorectomy.

    Authors: Kelly A Metcalfe, William D Foulkes, Henry T Lynch, Parviz Ghadirian, Nadine Tung, Ivo A Olivotto, Ellen Warner, Olufunmilayo Olopade, Andrea Eisen, Barbara Weber, Jane McLennan, Ping Sun and Steven A Narod

    Citation: Hereditary Cancer in Clinical Practice 2005 3:53

    Content type: Research

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  27. The NOD2 gene has been associated with susceptibility to Crohn's disease and individuals with Crohn's disease are at increased risk for cancer at a number of organ sites. We studied the association between the...

    Authors: Jan Lubiński, Tomasz Huzarski, Grzegorz Kurzawski, Janina Suchy, Bartłomiej Masojć, Marek Mierzejewski, Marcin Lener, Wenancjusz Domagała, Maria Chosia, Urszula Teodorczyk, Krzysztof Mędrek, Tadeusz Dębniak, Elżbieta Złowocka, Jacek Gronwald, Tomasz Byrski, Ewa Grabowska…

    Citation: Hereditary Cancer in Clinical Practice 2005 3:59

    Content type: Research

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  28. Chordoma is a rare mesenchymal tumour of complex biology for which only histologic and immunohistochemical criteria have been defined, but no biomarkers predicting the clinical outcome and response to treatmen...

    Authors: Lidia Larizza, Pietro Mortini and Paola Riva

    Citation: Hereditary Cancer in Clinical Practice 2005 3:29

    Content type: Review

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  29. A substantial minority of individuals who initially apply for genetic counselling for breast/ovarian cancer withdraw at an early stage from the counselling process. This study investigated the self-reported re...

    Authors: Eveline Bleiker, Gea Wigbout, Anja van Rens, Senno Verhoef, Laura van't Veer and Neil Aaronson

    Citation: Hereditary Cancer in Clinical Practice 2005 3:19

    Content type: Research

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