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  1. Several studies of survival in women with BRCA1 mutations have shown either reduced survival or no difference compared to controls. Programmes for early detection and treatment of inherited breast cancer, have fa...

    Authors: Anne Irene Hagen, Steinar Tretli, Lovise Mæhle, Jaran Apold, Nina Vedå and Pål Møller

    Citation: Hereditary Cancer in Clinical Practice 2009 7:7

    Content type: Research

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  2. Women at increased (genetic) risk of breast cancer have to weigh the personal pros and cons of prophylactic mastectomy (PM) as an option to reduce their cancer risk. So far, no routine referral to a psychologi...

    Authors: Murly BM Tan, Eveline MA Bleiker, Marian BE Menke-Pluymers, Arthur R Van Gool, Silvia van Dooren, Bert N Van Geel, Madeleine MA Tilanus-Linthorst, Karina CM Bartels, Jan GM Klijn, Cecile TM Brekelmans and Caroline Seynaeve

    Citation: Hereditary Cancer in Clinical Practice 2009 7:6

    Content type: Research

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  3. A significant portion of ovarian cancer (OC) cases is caused by germ-line mutations in BRCA1 or BRCA2 genes. BRCA testing is cheap in populations with founder effect and therefore recommended for all patients ...

    Authors: Evgeny N Suspitsin, Nathalia Yu Sherina, Daria N Ponomariova, Anna P Sokolenko, Aglaya G Iyevleva, Tatyana V Gorodnova, Olga A Zaitseva, Olga S Yatsuk, Alexandr V Togo, Nathalia N Tkachenko, Grigory A Shiyanov, Oksana S Lobeiko, Nadezhda Yu Krylova, Dmitry E Matsko, Sergey Ya Maximov, Adel F Urmancheyeva…

    Citation: Hereditary Cancer in Clinical Practice 2009 7:5

    Content type: Research

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  4. CHEK2 has previously been excluded as a major cause of Li-Fraumeni syndrome (LFS). One particular CHEK2 germline mutation, c.1100delC, has been shown to be associated with elevated breast cancer risk. The preval...

    Authors: Marielle WG Ruijs, Annegien Broeks, Fred H Menko, Margreet GEM Ausems, Anja Wagner, Rogier Oldenburg, Hanne Meijers-Heijboer, Laura J van't Veer and Senno Verhoef

    Citation: Hereditary Cancer in Clinical Practice 2009 7:4

    Content type: Research

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  5. Hereditary non-polyposis colorectal cancer (HNPCC), also known as Lynch syndrome, is an autosomal dominant inherited predisposition to a number of epithelial cancers, most notably colorectal and endometrial ca...

    Authors: Katie A Ashton, Anthony Proietto, Geoffrey Otton, Ian Symonds and Rodney J Scott

    Citation: Hereditary Cancer in Clinical Practice 2009 7:3

    Content type: Research

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  6. Although the probability of both parents being affected by BRCA1 mutations is not negligible, such families have not been systematically described in the literature. Here we present a large breast-ovarian canc...

    Authors: Anna P Sokolenko, Dmitry A Voskresenskiy, Aglaya G Iyevleva, Elena M Bit-Sava, Nadezhda I Gutkina, Maxim S Anisimenko, Nathalia Yu Sherina, Nathalia V Mitiushkina, Yulia M Ulibina, Olga S Yatsuk, Olga A Zaitseva, Evgeny N Suspitsin, Alexandr V Togo, Valery A Pospelov, Sergey P Kovalenko, Vladimir F Semiglazov…

    Citation: Hereditary Cancer in Clinical Practice 2009 7:2

    Content type: Case report

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  7. Authors: Jacek Gronwald, Tomasz Byrski, Tomasz Huzarski, Oleg Oszurek, Anna Janicka, Jolanta Szymańska-Pasternak, Bohdan Górski, Janusz Menkiszak, Izabella Rzepka-Górska and Jan Lubiński

    Citation: Hereditary Cancer in Clinical Practice 2008 6:88

    Content type: Review

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  8. Citation: Hereditary Cancer in Clinical Practice 2008 6:64

    Content type: Debate article

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  9. Lynch syndrome (HNPCC) is a dominantly inherited disorder characterized by germline defects in DNA mismatch repair (MMR) genes and the development of a variety of cancers, predominantly colorectal and endometr...

    Authors: Rein P. Stulp, Johanna C. Herkert, Arend Karrenbeld, Bart Mol, Yvonne J. Vos and Rolf H. Sijmons

    Citation: Hereditary Cancer in Clinical Practice 2008 6:15

    Content type: Research

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  10. In this paper we review clinical and genetic aspects of testicular germ cell tumours (TGCTs). TGCT is the most common type of malignant disorder in men aged 15-40 years. Its incidence has increased sharply in ...

    Authors: Martijn F. Lutke Holzik, Rolf H. Sijmons, Josette E.H.M. Hoekstra-Weebers, Dirk T. Sleijfer and Harald J. Hoekstra

    Citation: Hereditary Cancer in Clinical Practice 2008 6:3

    Content type: Review

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  11. Little is known about the aetiology of chronic lymphocytic leukaemia (CLL). The family medical history is a "genomic tool" capturing interactions of genetic susceptibility, shared environment and common behavi...

    Authors: Walter Weber, Patrick F. Maurer, Jacqueline Estoppey and Marcel Zwahlen

    Citation: Hereditary Cancer in Clinical Practice 2007 5:210

    Content type: Research

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  12. The correction of exogenous and endogenous environmental insult to DNA involves a series of DNA repair mechanisms that reduce the likelihood of mutation accumulation and hence an increased probability of tumou...

    Authors: Carla Kairupan and Rodney J. Scott

    Citation: Hereditary Cancer in Clinical Practice 2007 5:199

    Content type: Review

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  13. The molecular diagnostics of genetically conditioned disorders is based on the identification of the mutations in the predisposing genes. Hereditary cancer disorders of the gastrointestinal tracts are caused b...

    Authors: Andrzej Pławski, Marta Podralska and Ryszard Słomski

    Citation: Hereditary Cancer in Clinical Practice 2007 5:195

    Content type: Research

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  14. Hereditary diffuse gastric cancer (HDGC) is the only known predisposition syndrome dominated by carcinoma of the stomach and with a recognised genetic cause. Germline mutations in the E-cadherin gene (CDH1) co-se...

    Authors: Parry Guilford, Vanessa Blair, Helen More and Bostjan Humar

    Citation: Hereditary Cancer in Clinical Practice 2007 5:183

    Content type: Review

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  15. Men who carry mutations in BRCA1 or BRCA2 are at increased risk for prostate cancer. However the efficacy of prostate screening in this setting is uncertain and limited data exists on the uptake of prostate scree...

    Authors: Joanne M McKinley, Prue C Weideman, Mark A Jenkins, Michael L Friedlander, John L Hopper, Sue-Anne McLachlan, Geoffrey J Lindeman, kConFab Investigators and Kelly-Anne Phillips

    Citation: Hereditary Cancer in Clinical Practice 2007 5:161

    Content type: Research

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  16. To conduct a pilot population-based study within a general practice catchment area to determine whether the incidence of breast cancer was increased in the Ashkenazi population.

    Authors: Michelle Ferris, Douglas F Easton, Rebecca J Doherty, Brian HJ Briggs, Michelle Newman, Ifthikhar M Saraf, Sarah Scambler, Lyndon Wagman, Michael T Wyndham, Ann Ward and Rosalind A Eeles

    Citation: Hereditary Cancer in Clinical Practice 2007 5:157

    Content type: Research

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  17. BRCA1 and BRCA2 germ-line mutations occur in a significant number of unselected ovarian cancer (OC) patients, thus making a noticeable contribution to OC morbidity. It is of interest whether CHEK2, which is frequ...

    Authors: Nadezhda Yu Krylova, Daria N Ponomariova, Natalia Yu Sherina, Natalia Yu Ogorodnikova, Denis A Logvinov, Natalia V Porhanova, Oksana S Lobeiko, Adel F Urmancheyeva, Sergey Ya Maximov, Alexandr V Togo, Evgeny N Suspitsin and Evgeny N Imyanitov

    Citation: Hereditary Cancer in Clinical Practice 2007 5:153

    Content type: Research

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  18. Multiple myeloma (MM) is a relatively rare haematological malignancy seen in older persons. It has an unknown aetiology and usually occurs incidentally within a family. However, several families have been repo...

    Authors: Erica H Gerkes, Mirjam M de Jong, Rolf H Sijmons and Edo Vellenga

    Citation: Hereditary Cancer in Clinical Practice 2007 5:72

    Content type: Case report

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  19. This study examined: (1) levels of cancer-specific distress more than one year after genetic counselling for hereditary nonpolyposis colorectal cancer (HNPCC); (2) associations between sociodemographic, clinic...

    Authors: Eveline MA Bleiker, Fred H Menko, Irma Kluijt, Babs G Taal, Miranda A Gerritsma, Lidwina DV Wever and Neil K Aaronson

    Citation: Hereditary Cancer in Clinical Practice 2007 5:59

    Content type: Research

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  20. Polymorphisms in the ARLTS1 gene, a member of the Ras super-family, have been associated with susceptibility in different cancer types. The involvement of the gene in apoptotic signalling motivated us to study...

    Authors: Xuchen Li, Andreas Gast, Peter Rudnai, Eugene Gurzau, Kvetoslava Koppova, Kari Hemminki and Rajiv Kumar

    Citation: Hereditary Cancer in Clinical Practice 2007 5:25

    Content type: Research

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  21. Among Swedish families with an inherited predisposition for breast cancer, less than one third segregate mutations in genes known to be associated with an increased risk of breast cancer in combination with ot...

    Authors: Anna von Wachenfeldt, Annika Lindblom, Henrik Grönberg, Zakaria Einbeigi, Richard Rosenquist, Camilla Gardman and Lennart Iselius

    Citation: Hereditary Cancer in Clinical Practice 2007 5:17

    Content type: Research

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  22. This manuscript is composed of five parts which summarize five publications in succession. Essentially, they are concerned with molecular diagnostics of Lynch syndrome and are based on studies in 238 families....

    Authors: Grzegorz Kurzawski

    Citation: Hereditary Cancer in Clinical Practice 2006 4:197

    Content type: Research

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  23. The Swedish Family-Cancer Database has been used for some 10 years in the study of familial risks at all common sites. In the present paper we describe some of the main features of version VII of this Database...

    Authors: Kari Hemminki, Charlotta Granström, Jan Sundquist and Justo Lorenzo Bermejo

    Citation: Hereditary Cancer in Clinical Practice 2006 4:186

    Content type: Research

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  24. Cowden syndrome (multiple hamartoma syndrome, MIM 158350) is an early onset syndrome characterized by multiple hamartomas in the skin, mucous membranes, breast, thyroid and endometrium. Patients with Cowden sy...

    Authors: Cecilie F Rustad, Merete Bjørnslett, Ketil R Heimdal, Lovise Mæhle, Jaran Apold and Pål Møller

    Citation: Hereditary Cancer in Clinical Practice 2006 4:177

    Content type: Research

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  25. Molecular diagnostics of hereditary breast and/or ovarian cancer is mainly based on detection of BRCA1 and BRCA2 germline mutations in suspected families. The aim of the study was to determine the frequency, age ...

    Authors: Sona Ciernikova, Miroslav Tomka, Michal Kovac, Viola Stevurkova and Vladimir Zajac

    Citation: Hereditary Cancer in Clinical Practice 2006 4:7

    Content type: Research

    Published on:

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