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Prostate cancer is the most common cancer in men and the second highest cause of cancer-related mortality in the U.K. A genetic component in predisposition to prostate cancer has been recognized for decades. O...
Citation: Hereditary Cancer in Clinical Practice 2004 2:111
Citation: Hereditary Cancer in Clinical Practice 2004 2:149
Approximately 3-15% of all malignant melanomas (MM) are familial cases. MM is a highly heterogeneous tumour type from a genetic perspective. Pedigrees with disease confined to a single generation of siblings o...
Citation: Hereditary Cancer in Clinical Practice 2004 2:123
Citation: Hereditary Cancer in Clinical Practice 2004 2:147
We report three Dutch families with familial clustering of (pre)neoplastic cervical disease, review the literature on familial risks of cervical intraepithelial neoplasia (CIN) and cervical cancer, and discuss...
Citation: Hereditary Cancer in Clinical Practice 2004 2:99
Approximately 10% of gastric cancer cases show familial clustering but only 1-3% of gastric carcinomas arise as a result of inherited gastric cancer predisposition syndromes. Direct proof that Hereditary Gastr...
Citation: Hereditary Cancer in Clinical Practice 2004 2:51
Familial adenomatous polyposis (FAP) is characterized by the presence of hundreds to thousands of adenomas that carpet the entire colon and rectum. Nonsense and frameshift mutations in the adenomatous polyposi...
Citation: Hereditary Cancer in Clinical Practice 2004 2:81
To determine which individuals with colorectal cancer (CRC) were interested in knowing the results of their tumour microsatellite instability (MSI) and immunohistochemistry (IHC) testing. We were also interest...
Citation: Hereditary Cancer in Clinical Practice 2004 2:69
Gastric cancer is the second most frequently diagnosed malignancy worldwide and therefore represents a significant healthcare burden. Environmental and genetic factors are involved in the development of gastri...
Citation: Hereditary Cancer in Clinical Practice 2004 2:65
Central nervous system hemangioblastomas (cHAB) are rare tumours which most commonly arise in the cerebellum. Most tumours are sporadic, but as many as one third of cHABs occur in the course of the hereditary ...
Citation: Hereditary Cancer in Clinical Practice 2004 2:93
There is much debate in the literature about familial predispositions to breast and bowel cancers yet little evidence is forthcoming to suggest that there are susceptibility genes that can account for such kin...
Citation: Hereditary Cancer in Clinical Practice 2004 2:25
When BRCA1/2 genetic susceptibility testing was introduced in the clinic in the mid-nineties, the "Huntington protocol" was used in the counselling of individuals applying for genetic testing. This protocol inclu...
Citation: Hereditary Cancer in Clinical Practice 2004 2:19
Citation: Hereditary Cancer in Clinical Practice 2004 2:17
Options for the prevention of hereditary breast and ovarian cancer include screening, preventive surgery and chemoprevention. Screening studies with magnetic resonance imaging of the breast are promising but t...
Citation: Hereditary Cancer in Clinical Practice 2004 2:5
This paper highlights the need for carriers to be followed up by health professionals who understand the complexities of the BRCA syndrome. A BRCA carrier clinic has been established in London and regular follow ...
Citation: Hereditary Cancer in Clinical Practice 2004 2:77
Mutations in BRCA1 account for the majority of familial aggregations of early onset breast and ovarian cancer (~70%) and about 1/5 of all early onset breast cancer families; in contrast, mutations in BRCA2 accoun...
Citation: Hereditary Cancer in Clinical Practice 2004 2:37
The aim of the study is to evaluate the incidence and phenotype - genotype characteristics of hereditary colorectal cancer syndromes in Latvia in order to develop the basis of clinical management for patients ...
Citation: Hereditary Cancer in Clinical Practice 2003 1:49
Denaturing high performance liquid chromatography is a relatively new method by which heteroduplex structures formed during the PCR amplification of heterozygote samples can be rapidly identified. The use of t...
Citation: Hereditary Cancer in Clinical Practice 2003 1:39
The criteria for the diagnosis of HNPCC established by the ICG-HNPCC are very restrictive as they do not allow for the diagnosis of a large number of "suspected HNPCC" cases - these are families which do no fu...
Citation: Hereditary Cancer in Clinical Practice 2003 1:34
In addition to a relatively small number of well known hereditary cancer syndromes, hundreds of presumed or proven hereditary disorders have been observed to manifest cancer as a characteristic feature or as a...
Citation: Hereditary Cancer in Clinical Practice 2003 1:31
There have been significant advances in our knowledge about the molecular changes that precede and accompany the development of inherited predispositions to colorectal cancer. In this review the clinical relat...
Citation: Hereditary Cancer in Clinical Practice 2003 1:19
HNPCC (Lynch syndrome) is the most common form of hereditary colorectal cancer (CRC), wherein it accounts for between 2-7 percent of the total CRC burden. When considering the large number of extracolonic canc...
Citation: Hereditary Cancer in Clinical Practice 2003 1:7
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Hereditary Cancer in Clinical Practice
