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  1. The correction of exogenous and endogenous environmental insult to DNA involves a series of DNA repair mechanisms that reduce the likelihood of mutation accumulation and hence an increased probability of tumou...

    Authors: Carla Kairupan and Rodney J. Scott

    Citation: Hereditary Cancer in Clinical Practice 2007 5:199

    Content type: Review

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  2. Hereditary diffuse gastric cancer (HDGC) is the only known predisposition syndrome dominated by carcinoma of the stomach and with a recognised genetic cause. Germline mutations in the E-cadherin gene (CDH1) co-se...

    Authors: Parry Guilford, Vanessa Blair, Helen More and Bostjan Humar

    Citation: Hereditary Cancer in Clinical Practice 2007 5:183

    Content type: Review

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  3. Men who carry mutations in BRCA1 or BRCA2 are at increased risk for prostate cancer. However the efficacy of prostate screening in this setting is uncertain and limited data exists on the uptake of prostate scree...

    Authors: Joanne M McKinley, Prue C Weideman, Mark A Jenkins, Michael L Friedlander, John L Hopper, Sue-Anne McLachlan, Geoffrey J Lindeman, kConFab Investigators and Kelly-Anne Phillips

    Citation: Hereditary Cancer in Clinical Practice 2007 5:161

    Content type: Research

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  4. To conduct a pilot population-based study within a general practice catchment area to determine whether the incidence of breast cancer was increased in the Ashkenazi population.

    Authors: Michelle Ferris, Douglas F Easton, Rebecca J Doherty, Brian HJ Briggs, Michelle Newman, Ifthikhar M Saraf, Sarah Scambler, Lyndon Wagman, Michael T Wyndham, Ann Ward and Rosalind A Eeles

    Citation: Hereditary Cancer in Clinical Practice 2007 5:157

    Content type: Research

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  5. BRCA1 and BRCA2 germ-line mutations occur in a significant number of unselected ovarian cancer (OC) patients, thus making a noticeable contribution to OC morbidity. It is of interest whether CHEK2, which is frequ...

    Authors: Nadezhda Yu Krylova, Daria N Ponomariova, Natalia Yu Sherina, Natalia Yu Ogorodnikova, Denis A Logvinov, Natalia V Porhanova, Oksana S Lobeiko, Adel F Urmancheyeva, Sergey Ya Maximov, Alexandr V Togo, Evgeny N Suspitsin and Evgeny N Imyanitov

    Citation: Hereditary Cancer in Clinical Practice 2007 5:153

    Content type: Research

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  6. Multiple myeloma (MM) is a relatively rare haematological malignancy seen in older persons. It has an unknown aetiology and usually occurs incidentally within a family. However, several families have been repo...

    Authors: Erica H Gerkes, Mirjam M de Jong, Rolf H Sijmons and Edo Vellenga

    Citation: Hereditary Cancer in Clinical Practice 2007 5:72

    Content type: Case report

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  7. This study examined: (1) levels of cancer-specific distress more than one year after genetic counselling for hereditary nonpolyposis colorectal cancer (HNPCC); (2) associations between sociodemographic, clinic...

    Authors: Eveline MA Bleiker, Fred H Menko, Irma Kluijt, Babs G Taal, Miranda A Gerritsma, Lidwina DV Wever and Neil K Aaronson

    Citation: Hereditary Cancer in Clinical Practice 2007 5:59

    Content type: Research

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  8. Polymorphisms in the ARLTS1 gene, a member of the Ras super-family, have been associated with susceptibility in different cancer types. The involvement of the gene in apoptotic signalling motivated us to study...

    Authors: Xuchen Li, Andreas Gast, Peter Rudnai, Eugene Gurzau, Kvetoslava Koppova, Kari Hemminki and Rajiv Kumar

    Citation: Hereditary Cancer in Clinical Practice 2007 5:25

    Content type: Research

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  9. Among Swedish families with an inherited predisposition for breast cancer, less than one third segregate mutations in genes known to be associated with an increased risk of breast cancer in combination with ot...

    Authors: Anna von Wachenfeldt, Annika Lindblom, Henrik Grönberg, Zakaria Einbeigi, Richard Rosenquist, Camilla Gardman and Lennart Iselius

    Citation: Hereditary Cancer in Clinical Practice 2007 5:17

    Content type: Research

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  10. This manuscript is composed of five parts which summarize five publications in succession. Essentially, they are concerned with molecular diagnostics of Lynch syndrome and are based on studies in 238 families....

    Authors: Grzegorz Kurzawski

    Citation: Hereditary Cancer in Clinical Practice 2006 4:197

    Content type: Research

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  11. The Swedish Family-Cancer Database has been used for some 10 years in the study of familial risks at all common sites. In the present paper we describe some of the main features of version VII of this Database...

    Authors: Kari Hemminki, Charlotta Granström, Jan Sundquist and Justo Lorenzo Bermejo

    Citation: Hereditary Cancer in Clinical Practice 2006 4:186

    Content type: Research

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  12. Cowden syndrome (multiple hamartoma syndrome, MIM 158350) is an early onset syndrome characterized by multiple hamartomas in the skin, mucous membranes, breast, thyroid and endometrium. Patients with Cowden sy...

    Authors: Cecilie F Rustad, Merete Bjørnslett, Ketil R Heimdal, Lovise Mæhle, Jaran Apold and Pål Møller

    Citation: Hereditary Cancer in Clinical Practice 2006 4:177

    Content type: Research

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  13. Molecular diagnostics of hereditary breast and/or ovarian cancer is mainly based on detection of BRCA1 and BRCA2 germline mutations in suspected families. The aim of the study was to determine the frequency, age ...

    Authors: Sona Ciernikova, Miroslav Tomka, Michal Kovac, Viola Stevurkova and Vladimir Zajac

    Citation: Hereditary Cancer in Clinical Practice 2006 4:7

    Content type: Research

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  14. Whereas HER2 amplification is a well-known phenomenon in breast tumours, its frequency and clinical importance in ovarian cancer have not been established. The aim of the study was to compare the frequency of HER...

    Authors: Izabela Brożek, Iwona Kardaś, Karolina Ochman, Jarosław Dębniak, Maciej Stukan, Magdalena Ratajska, Lucyna Morzuch, Janusz Emerich and Janusz Limon

    Citation: Hereditary Cancer in Clinical Practice 2006 4:39

    Content type: Research

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  15. The majority of hereditary breast and ovarian cancers can be accounted for by germline mutations in the BRCA1 and BRCA2 genes. Genetic counselling and testing in high-risk patients in the Czech Republic began ...

    Authors: Lenka Foretova, Katarina Petrakova, Marketa Palacova, Renata Kalabova, Marie Navratilova, Miroslava Lukesova, Petra Vasickova, Eva Machackova, Zdenek Kleibl and Petr Pohlreich

    Citation: Hereditary Cancer in Clinical Practice 2006 4:3

    Content type: Research

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  16. Paragangliomas are rare tumours of the autonomic nervous system and occur in sporadic and hereditary forms. They are usually benign and have a low mortality. However, they cause significant morbidity related t...

    Authors: CJM Lips, EGWM Lentjes, JWM Höppener, RB van der Luijt and FL Moll

    Citation: Hereditary Cancer in Clinical Practice 2006 4:169

    Content type: Review

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  17. The BRCA1 4153delA allele is frequently referred to as the Russian founder mutation, as it was initially detected in several cancer families from Moscow. Our earlier studies have demonstrated 1% occurrence of ...

    Authors: Nadezhda Yu Krylova, Oksana S Lobeiko, Anna P Sokolenko, Aglaya G Iyevleva, Maxim E Rozanov, Natalia V Mitiushkina, Madina M Gergova, Tatiana V Porhanova, Adel F Urmancheyeva, Sergey Ya Maximov, Alexandr V Togo and Evgeny N Imyanitov

    Citation: Hereditary Cancer in Clinical Practice 2006 4:193

    Content type: Research

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    The Erratum to this article has been published in Hereditary Cancer in Clinical Practice 2007 5:56

  18. This study was undertaken to determine: 1) Type and prevalence of founder mutations BRCA1 and BRCA2 genes in Polish families with strong aggregation of breast and/or ovarian cancer. 2) Risk of breast and/or ovari...

    Authors: Bohdan Górski

    Citation: Hereditary Cancer in Clinical Practice 2006 4:142

    Content type: Research

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  19. A family is reported in which three male siblings of Asian descent developed non-Hodgkin's lymphoma (NHL). Case 1 was diagnosed with indolent follicular lymphoma stage IIIA at age 45. Case 2 presented with lar...

    Authors: Sandra S.C.M. Loves, Lieuwe de Haan and Simon M.G.J. Daenen

    Citation: Hereditary Cancer in Clinical Practice 2006 4:136

    Content type: Case report

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  20. MTC is a rare neuroendocrine thyroid tumour accounting for 3% to 10% of all thyroid malignancies. It can occur in a sporadic and a hereditary clinical setting. Hereditary MTC may either occur alone (familial M...

    Authors: Jan Willem de Groot, Thera P. Links, Robert M.W. Hofstra and John T.M. Plukker

    Citation: Hereditary Cancer in Clinical Practice 2006 4:115

    Content type: Review

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  21. Xeroderma pigmentosum (XP) is a rare recessive disorder that is characterized by extreme sensitivity to UV light. UV light exposure results in the formation of DNA damage such as cyclobutane dimers and (6-4) p...

    Authors: Nikola A. Bowden, Paul A. Tooney and Rodney J. Scott

    Citation: Hereditary Cancer in Clinical Practice 2006 4:103

    Content type: Research

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  22. Catechol-O-methyltransferase (COMT) is vital for the conjugation of catechol estrogens that are produced during oestrogen metabolism. The efficiency of this process varies due to a polymorphism in COMT, which ...

    Authors: Katie A. Ashton, Cliff J. Meldrum, Mary L. McPhillips, Janina Suchy, Grzegorz Kurzawski, Jan Lubinski and Rodney J. Scott

    Citation: Hereditary Cancer in Clinical Practice 2006 4:94

    Content type: Research

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  23. Recently, carriers of biallelic mutations in the base excision repair gene MUTYH, have been demonstrated to have a predisposition for multiple adenomas and colorectal cancer. Still, many questions remain unanswer...

    Authors: Astrid Stormorken, Karen-Marie Heintz, Per Arne Andresen, Eivind Hovig and Pål Møller

    Citation: Hereditary Cancer in Clinical Practice 2006 4:90

    Content type: Research

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  24. Childhood adrenocortical tumour (ACT) is not a common disease, but in southern Brazil the prevalence is 15 times higher than in other parts of the world. One hundred and thirty-seven patients have been identif...

    Authors: Rosana Marques-Pereira, Luiz DeLacerda, Hadriano M Lacerda, Edson Michalkiewicz, Fabiano Sandrini and Romolo Sandrini

    Citation: Hereditary Cancer in Clinical Practice 2006 4:81

    Content type: Review

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  25. Global analysis of gene expression by DNA microarrays is nowadays a widely used tool, especially relevant for cancer research. It helps the understanding of complex biology of cancer tissue, allows identificat...

    Authors: Volha Dudaladava, Michał Jarząb, Ewa Stobiecka, Ewa Chmielik, Krzysztof Simek, Tomasz Huzarski, Jan Lubiński, Jolanta Pamuła, Wioletta Pękala, Ewa Grzybowska and Katarzyna Lisowska

    Citation: Hereditary Cancer in Clinical Practice 2006 4:28

    Content type: Research

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  26. Authors: Tadeusz Dębniak, Cezary Cybulski, Grzegorz Kurzawski, Bohdan Górski, Tomasz Huzarski, Tomasz Byrski, Jacek Gronwald, Janina Suchy, Bartłomiej Masojć, Marek Mierzejewski, Marcin Lener, Urszula Teodorczyk, Krzysztof Mędrek, Elżbieta Złowocka, Ewa Grabowska-Kłujszo, Katarzyna Nej-Wołosiak…

    Citation: Hereditary Cancer in Clinical Practice 2006 4:52

    Content type: Short report

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  27. It has not been established whether CHEK2 and NOD2 variants are present in Latvia and whether inherited variation in these genes influences cancer risk in this population.

    Authors: Arvids Irmejs, Edvins Miklasevics, Viktors Boroschenko, Andris Gardovskis, Andrejs Vanags, Inga Melbarde-Gorkusa, Marianna Bitina, Janina Suchy and Janis Gardovskis

    Citation: Hereditary Cancer in Clinical Practice 2006 4:48

    Content type: Research

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  28. Familial Adenomatous Polyposis (FAP) is an inheritable predisposition for the occurrence of numerous polyps in the large intestine. In about 50% of all patients, the occurrence of the disease is conditioned by...

    Authors: Marzena Skrzypczak, Marta Podralska, Wolfram Heinritz, Ursula G Froster, Daniel Lipiński, Ryszard Słomski and Andrzej Pławski

    Citation: Hereditary Cancer in Clinical Practice 2006 4:43

    Content type: Research

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