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Fig. 2 | Hereditary Cancer in Clinical Practice

Fig. 2

From: Prevalence of BRCA1 and BRCA2 germline variants in an unselected pancreatic cancer patient cohort in Pakistan

Fig. 2

Representative HRM difference plots and DNA sequencing chromatograms of BRCA1/2 analysis. Normalized and temperature-shifted difference plots of the BRCA1 (a) and BRCA2 (b) showing the discrimination of positive controls and the variant-carriers (PDA 031 and PDA 121) from the wildtypes. DNA sequencing chromatograms of forward DNA strand of wildtypes (c, d), the patient PDA 031 (e) showing a BRCA1 variant (c.878C > G) and the patient PDA 121 (f) showing a BRCA2 variant (c.7948G > C) as indicated by an arrow

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Hereditary Cancer in Clinical Practice

ISSN: 1897-4287