Simultaneous bilateral mastectomy and RRSO for BRCA2-positive non-invasive breast cancer in Japan: a case report and analysis of initial experience

Table 1 Cases of risk-reducing surgery performed at our hospital through March 2022

Case	Variant	Age at first onset of breast cancer (years)	Age at diagnosis of HBOC (years)	Age at RRSO (years)	Age at CRRM (years)	Payment for risk-reducing surgery
1	BRCA1	28	41	42	not performed	self-funded
2	BRCA1	39	39	40	40	insurance
3	BRCA1	41	43	43	not performed	insurance
4	BRCA1	48	48	49	53	self-funded
5	BRCA1	50	50	51	not performed	insurance
6	BRCA2	43	46	47	not performed	insurance
7	BRCA2	57	59	60	not performed	insurance
8	BRCA2	64	63	64	64	insurance

Note: Most cases underwent surgery after obtaining insurance coverage, but in some cases risk-reducing surgery was performed on a self-funded basis. All cases of RRSO have been performed so far, all within one year of HBOC diagnosis. CRRM was also performed in 3 cases, as the procedure was covered by insurance. Case 2 underwent breast cancer surgery and CRRM at the same time, followed by reconstruction, then RRSO after 2 months. In Case 3, RRSO revealed cancer in the ovary and fallopian tube, and radical surgery was performed later. Stage II ovarian cancer was diagnosed. This time, we introduce the eighth case, representing the first case in which breast surgery and ovarian/fallopian tube surgery were performed on the same day in our hospital

ISSN: 1897-4287