Table 2 Bethesda criteria [24, 25, 28]
From: Diagnosis of patients with Lynch syndrome lacking the Amsterdam II or Bethesda criteria
Original Bethesda Criteria (1997) |
Tumors from individuals should be evaluated for MSI in the following situations: 1-Individuals with cancer in families that meet the Amsterdam criteria 2-Individuals with two HNPCC-related cancers, including synchronous and metachronous colorectal cancers or associated extracolonic cancers 3-Individuals with colorectal cancer and a first-degree relative with colorectal cancer and/or an extracolonic cancer associated with HNPCC and/or a colorectal adenoma; one of the cancers diagnosed before the age of 45 and the adenoma diagnosed before the age of 40 4-Individuals with colorectal cancer or endometrial cancer diagnosed before the age of 45 5-Individuals with right-sided colorectal cancer with an undifferentiated pattern (solid/cribriform) on histopathology diagnosed before the age of 45 years 6-Individuals with signet ring cell colorectal cancer diagnosed before the age of 45 7-Individuals with adenomas diagnosed before the age of 40 |
Revised Bethesda Criteria (2004) |
Tumors from individuals should be evaluated for MSI in the following situations: 1- Colorectal cancer diagnosed in a patient under 50 years of age 2-Presence of synchronous or metachronous colorectal tumors or other tumors associated with HNPCC, regardless of age. 3- Colorectal cancer with MSI-H histology diagnosed in a patient under 60 years of age 4- Colorectal cancer or a tumor associated with HNPCC diagnosed in one or more first-degree relatives, with one of the cancers diagnosed before the age of 50 years 5- Colorectal cancer or HNPCC-associated tumors diagnosed in two or more first- or second-degree relatives, regardless of age |