Table 1 Amsterdam I and II clinical criteria [14, 15]
From: Diagnosis of patients with Lynch syndrome lacking the Amsterdam II or Bethesda criteria
Amsterdam I (1991) |
There must be at least three relatives with colorectal cancer; all the following criteria must be present: 1-One of the cases must be a first-degree relative of the other two 2-At least two successive generations must be affected 3-At least one case must have been diagnosed before the age of 50 4-Familial Adenomatous Polyposis must be excluded 5-Tumors must be verified by pathological examination |
Amsterdam II (1999) |
There must be at least three relatives with an HNPCC-associated cancer (colorectal cancer, cancer of the endometrium, small intestine, ureter, or renal pelvis) 1-One of the cases must be a first-degree relative of the other two 2-At least two successive generations must be affected 3-At least one must be diagnosed before the age of 50 4-Familial Adenomatous Polyposis should be excluded in cases of colorectal cancer 5-Tumors must be verified by pathological examination |