Table 7 Risk factors for development of stage IV (n = 146)

Sex

Male

Female

9 (33)

18 (67)

54 (45)

65 (55)

0.35

Body mass index, kg/m²

20.7 (14.7–30.1)

21.0 (16.8–27.5)

0.51

Alcohol intake

Past/current drinker

Never-drinker

13 (48)

14 (52)

59 (50)

60 (50)

0.94

Smoking

Past/current smoker

Never-smoker

5 (19)

22 (81)

31 (26)

88 (74)

0.57

Family history of FAP

Positive

Negative

Unknown

24 (89)

1 (4)

2 (7)

102 (86)

7 (6)

10 (8)

0.98

Helicobacter pylori status

Positive

Negative

Unknown

6 (22)

20 (74)

1 (4)

22 (18)

92 (77)

5 (4)

0.91

History of colorectal cancer

Positive

Negative

3 (11)

24 (89)

7 (6)

112 (94)

0.58

Type of polyposis

Classic FAP

Attenuated FAP

26 (96)

1 (4)

107 (90)

12 (10)

0.50

Age at diagnosis of FAP, years

25 (15–53)

26 (14–64)

0.88

Colectomy

Positive

Negative

14 (52)

13 (48)

33 (28)

86 (72)

0.02

Adenoma size of ≥ 10 mm

Positive

Negative

3 (11)

24 (89)

4 (3)

115 (97)

0.22

Duodenal ampullary adenoma

Positive

Negative

5 (19)

22 (81)

16 (13)

103 (87)

0.71

Site ofAPC mutation (mutation at codons 279–1309)*

Mutation within the region

Mutation outside the region

17 (63)

8 (30)

62 (52)

44 (37)

0.52

Site ofAPC mutation*

3’: distal mutation group from codon 1051

5’: proximal mutation group from codon 1051

7 (26)

18 (67)

40 (34)

66 (55)

0.50

Site ofAPC mutation*

3’: distal mutation group (exons 10–15)

5’: proximal mutation group (exons 1–9)

20 (74)

5 (19)

66 (55)

40 (34)

0.15

Site ofAPC mutation (mutation at codons 1401–1580)*

Mutation within the region

Mutation outside the region

1 (4)

24 (89)

5 (4)

101 (85)

0.71

Site ofAPC mutation (mutation at codons 1250–1460)*

Mutation within the region

Mutation outside the region

3 (11)

22 (81)

8 (7)

98 (82)

0.75