Table 6 Risk factors for development of HGD (n = 146)

Sex

Male

Female

11 (34)

21 (66)

52 (46)

62 (54)

0.26

Body mass index, kg/m²

21.6 (14.7–30.1)

20.9 (16.8–27.5)

0.89

Alcohol intake

Past/current drinker

Never-drinker

15 (47)

17 (53)

57 (50)

57 (50)

0.75

Smoking

Past/current smoker

Never-smoker

5 (16)

27 (84)

31 (27)

83 (73)

0.27

Family history of FAP

Positive

Negative

Unknown

30 (93)

1 (3)

1 (3)

96 (84)

7 (6)

11 (10)

0.66

Helicobacter pylori status

Positive

Negative

Unknown

5 (16)

26 (81)

1 (3)

23 (20)

86 (75)

5 (4)

0.92

History of colorectal cancer

Positive

Negative

4 (12)

28 (88)

6 (5)

108 (95)

0.30

Type of polyposis

Classic FAP

Attenuated FAP

30 (94)

2 (6)

103 (90)

11 (10)

0.81

Age at diagnosis of FAP, years

26 (15–59)

26 (13–64)

0.59

Colectomy

Positive

Negative

17 (53)

15 (47)

30 (26)

84 (74)

0.004

Adenoma size of ≥ 10 mm

Positive

Negative

4 (13)

28 (88)

3 (3)

111 (97)

0.07

Duodenal ampullary adenoma

Positive

Negative

7 (22)

25 (78)

14 (12)

100 (88)

0.28

Site ofAPC mutation (mutation at codons 279–1309)*

Mutation within the region

Mutation outside the region

18 (56)

13 (41)

61 (54)

39 (34)

0.77

Site ofAPC mutation*

3’: distal mutation group from codon 1051

5’: proximal mutation group from codon 1051

10 (31)

21 (66)

37 (32)

63 (55)

0.63

Site ofAPC mutation*

3’: distal mutation group (exons 10–15)

5’: proximal mutation group (exons 1–9)

22 (69)

9 (28)

64 (56)

36 (32)

0.62

Site ofAPC mutation (mutation at codons 1401–1580)*

Mutation within the region

Mutation outside the region

2 (6)

29 (90)

4 (4)

96 (84)

0.94

Site ofAPC mutation (mutation at codons 1250–1460)*

Mutation within the region

Mutation outside the region

4 (13)

27 (84)

7 (6)

93 (82)

0.51