Table 5 Risk factors for development of ≥ 10-mm adenoma (n = 146)

Sex

Male

Female

16 (43)

21 (57)

47 (43)

62 (57)

0.99

Body mass index, kg/m²

20.9 (14.7–30.1)

21.0 (15.6–37.2)

0.80

Alcohol intake

Past/current drinker

Never-drinker

21 (57)

16 (43)

51 (47)

58 (53)

0.29

Smoking

Past/current smoker

Never-smoker

8 (22)

29 (78)

28 (26)

81 (74)

0.78

Family history of FAP

Positive

Negative

Unknown

32 (86)

1 (3)

4 (10)

94 (86)

7 (6)

8 (7)

0.87

Helicobacter pylori status

Positive

Negative

Unknown

6 (16)

28 (76)

3 (8)

22 (20)

84 (77)

3 (3)

0.63

History of colorectal cancer

Positive

Negative

6 (16)

31 (84)

4 (4)

105 (96)

0.03

Type of polyposis

Classic FAP

Attenuated FAP

37 (100)

0 (0)

96 (88)

13 (12)

0.06

Age at diagnosis of FAP, years

29 (15–59)

25 (13–64)

0.22

Colectomy

Positive

Negative

23 (62)

14 (38)

24 (22)

85 (78)

< 0.001

Duodenal ampullary adenoma

Positive

Negative

6 (16)

31 (84)

15 (14)

94 (86)

0.92

Site ofAPC mutation (mutation at codons 279–1309)*

Mutation within the region

Mutation outside the region

26 (70)

9 (24)

53 (49)

43 (39)

0.08

Site ofAPC mutation*

3’: distal mutation group from codon 1051

5’: proximal mutation group from codon 1051

15 (40)

20 (54)

32 (29)

64 (59)

0.31

Site ofAPCmutation*

3’: distal mutation group (exons 10–15)

29 (78)

57 (52)

0.02

5’: proximal mutation group (exons 1–9)

6 (16)

39 (36)

Site ofAPC mutation (mutation at codons 1401–1580)*

Mutation within the region

Mutation outside the region

2 (5)

33 (89)

4 (4)

92 (84)

0.92

Site ofAPC mutation (mutation at codons 1250–1460)*

Mutation within the region

Mutation outside the region

3 (8)

32 (86)

7 (6)

89 (82)

0.90