Table 4 Progression of patients with stage 0 to I (n = 72)

Sex

Male

Female

25 (42)

35 (58)

4 (33)

8 (67)

0.83

Body mass index, kg/m²

20.7 (14.7–36.2)

23.1 (19.1–27.3)

0.09

Alcohol intake

Past/current drinker

Never-drinker

30 (50)

30 (50)

6 (50)

6 (50)

0.75

Smoking

Past/current smoker

Never-smoker

17 (28)

43 (72)

1 (8)

11 (92)

0.27

Family history of FAP

Positive

Negative

Unknown

52 (87)

4 (7)

4 (7)

9 (75)

0 (0)

3 (25)

0.38

Helicobacter pylori status

Positive

Negative

Unknown

8 (13)

50 (83)

2 (3)

4 (33)

8 (67)

0 (0)

0.45

History of colorectal cancer

Positive

Negative

6 (10)

54 (90)

0 (0)

12 (100)

0.57

Type of polyposis

Classic FAP

Attenuated FAP

58 (97)

2 (3)

3 (25)

9 (75)

< 0.001

Age at diagnosis of FAP, years

25.5 (13–49)

37.5 (30–64)

< 0.001

Colectomy

Positive

Negative

25 (42)

35 (58)

1 (8)

11 (92)

0.06

Duodenal ampullary adenoma

Positive

Negative

11 (18)

49 (82)

0 (0)

12 (100)

0.24

Site ofAPC mutation (mutation at codons 279–1309)*

Mutation within the region

Mutation outside the region

27 (45)

27 (45)

8 (67)

1 (8)

0.07

Site ofAPC mutation*

3’: distal mutation group from codon 1051

5’: proximal mutation group from codon 1051

17 (28)

37 (62)

4 (7)

5 (8)

0.70

Site ofAPC mutation*

3’: distal mutation group (exons 10–15)

5’: proximal mutation group (exons 1–9)

27 (45)

27 (45)

7 (58)

2 (17)

0.23

Site ofAPC mutation (mutation at codons 1401–1580)*

Mutation within the region

Mutation outside the region

2 (3)

52 (87)

0 (0)

9 (75)

0.66

Site ofAPC mutation (mutation at codons 1250–1460)*

Mutation within the region

Mutation outside the region

3 (5)

51 (85)

0 (0)

9 (75)

0.90