Table 3 Progression of patients with stage 0 to III (n = 113)

Sex

Male

Female

34 (43)

46 (58)

12 (36)

21 (64)

0.55

Body mass index, kg/m²

20.7 (14.7–36.2)

21.9 (15.6–27.3)

0.80

Alcohol intake

Past/current drinker

Never-drinker

39 (49)

41 (51)

13 (39)

20 (61)

0.36

Smoking

Past/current smoker

Never-smoker

19 (24)

61 (76)

7 (21)

26 (79)

0.96

Family history of FAP

Positive

Negative

Unknown

69 (86)

6 (8)

5 (6)

29 (88)

1 (3)

3 (9)

0.90

Helicobacter pylori status

Positive

Negative

Unknown

12 (15)

66 (83)

2 (3)

8 (24)

25 (76)

0 (0)

0.69

History of colorectal cancer

Positive

Negative

6 (8)

74 (93)

1 (3)

32 (97)

0.64

Type of polyposis

Classic FAP

Attenuated FAP

77 (96)

3 (4)

23 (70)

10 (30)

<0.001

Age at diagnosis of FAP, years

24 (13–49)

27 (16–64)

0.08

Colectomy

Positive

Negative

33 (41)

47 (59)

5 (15)

28 (85)

0.01

Duodenal ampullary adenoma

Positive

Negative

14 (18)

66 (83)

4 (12)

29 (88)

0.67

Site ofAPC mutation (mutation at codons 279–1309)*

Mutation within the region

Mutation outside the region

41 (51)

33 (41)

20 (60)

8 (24)

0.21

Site ofAPC mutation*

3’: distal mutation group from codon 1051

5’: proximal mutation group from codon 1051

23 (29)

51 (64)

14 (42)

14 (42)

0.08

Site ofAPC mutation*

3’: distal mutation group (exons 10–15)

5’: proximal mutation group (exons 1–9)

44 (55)

30 (38)

21 (64)

7 (21)

0.22

Site ofAPC mutation (mutation at codons 1401–1580)*

Mutation within the region

Mutation outside the region

4 (5)

70 (88)

0 (0)

28 (85)

0.49

Site ofAPC mutation (mutation at codons 1250–1460)*

Mutation within the region

Mutation outside the region

7 (9)

67 (84)

0 (0)

28 (85)

0.21