Skip to main content

Table 1 High-risk cancer screening protocol recommended by the UVA LFS clinic, based on the modified Toronto Protocol.(1) wbMRI = whole body MRI, US= ultrasound, EGD= esophagogastroduodenoscopy, CBC= complete blood count, LDH= lactate dehydrogenase, 17-OHP= 17-hydroxyprogesterone, DHEAS= dehydroepiandrosterone

From: Factors affecting adherence to a high-risk surveillance protocol among patients with Li-Fraumeni syndrome

 

UVA LFS Clinic Surveillance Protocol

Toronto Protocol

Test

Frequency

Frequency

wbMRI

annually

annually

Breast MRI (for females)

annually

annually, in addition to annual mammogram

Brain MRI

annually

annually

Abdominal US

annually

every 3–4 months

Pelvic US (for females with reproductive organs)

annually

every 3–4 months

Colonoscopy/EGD

every 2 years

every 2 years

Skin exam

annually

annually

Labs (CBC, LDH, ESR, 17-OHP, total testosterone, DHEAS, androstenedione)

not routinely assessed

every 3–4 months