Table 2 Clinical characteristics of deficient mismatch repair cases
P-MA group n = 26 | MA group n = 26 | P-value | |
|---|---|---|---|
Age at surgery, years, n (%) | 0.37 | ||
< 70 | 6 (23.1) | 10 (38.5) | |
70 | 20 (76.9) | 16 (61.5) | |
Sex, male/female | 12/14 | 16/10 | 0.40 |
Family history of colorectal cancer, n (%) | 0.60* | ||
Yes | 6 (23.1) | 6 (23.1) | |
No | 19 (73.1) | 20 (76.9) | |
Unknown | 1 (3.8) | 0 (0) | |
Synchronous colorectal cancer, n (%) | 1 (3.8) | 3 (11.5) | 0.61 |
Metachronous colorectal cancer, n (%) | 4 (15.4) | 4 (15.4) | 1.00 |
Tumor location, n (%) | 0.99* | ||
Right colon | 24 (92.3) | 22 (84.6) | |
Left colon | 1 (3.8) | 2 (7.7) | |
Rectum | 1 (3.8) | 2 (7.7) | |
Tumor histology, n (%) | 0.91** | ||
Tubular adenocarcinoma | 15 (57.7) | 19 (73.1) | |
Poorly differentiated adenocarcinoma | 1 (3.8) | 1 (3.8) | |
Mucinous | 6 (23.1) | 4 (15.4) | |
Others | 4 (15.4) | 2 (7.7) | |
Pathological stage*, m (%) | 0.25*** | ||
0 | 1 (3.8) | 1 (3.8) | |
I | 3 (11.5) | 9 (34.6) | |
II | 15 (57.7) | 12 (46.2) | |
III | 7 (26.9) | 4 (15.4) | |
IV | 0 (0) | 0 (0) | |
MMRP IHC, n | 0.97*** | ||
MLH1 and PMS2 deficient | 23 (88.5) | 22 (84.6) | |
MSH2 and MSH6 deficient | 1 (3.8) | 2 (7.7) | |
PMS2 deficient only | 0 (0) | 1 (3.8) | |
MSH6 deficient only | 2 (7.7) | 0 (0) | |
Null phenotype | 0 (0) | 1 (3.8) |