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Fig. 2 | Hereditary Cancer in Clinical Practice

Fig. 2

From: Using a multistep approach with multidisciplinary team to increase the diagnosis rate of Lynch syndrome-associated colorectal cancer after universal screening: a single-center study in Japan

Fig. 2

The flow chart of universal screening for Lynch syndrome in the multidisciplinary team management

In the case of expression loss of both MLH1 and PMS2, after case selection by surgeons, the eligible patients received a step-by-step explanation about the genetic disease in pre-genetic and genetic counseling. In the case of a protein expression loss pattern other than MLH1 and PMS2, all patients received a step-by-step explanation about the genetic disease in pre-genetic and genetic counseling

dMMR: deficient MMR, LS: Lynch syndrome, LLS: Lynch-like syndrome, CRC: colorectal cancer

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Hereditary Cancer in Clinical Practice

ISSN: 1897-4287