Fig. 2From: Beyond germline genetic testing - heterozygous pathogenic variants in PMS2 in two children with Osteosarcoma and EpendymomaCR1: (A) Hematoxylin and eosin staining of the nuchal metastasis of the osteosarcoma. Immunohistochemical (IHC) staining of mismatch repair proteins demonstrating loss of PMS2 expression in (B) neoplastic cells and (C) retained nuclear expression of MSH6 in the tumor cells. CR2: (D) Hematoxylin and eosin staining of the 2nd relapse of ependymoma. IHC of mismatch repair proteins demonstrating nuclear expression of PMS2 (E) and MSH6 (F) in the tumor cells. A-B, D-F: 40x magnification. C: 100x magnificationBack to article page