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Table 2 Concordant familial risks when one or at least two probands were diagnosed with cancer. Modified from ref. [9]

From: Are population level familial risks and germline genetics meeting each other?

 

One family member diagnosed with concordant cancer

Two or more family members diagnosed with concordant cancer

Cancer site

O

Mean age ± SD

SIR

95% CI

O

Mean age ± SD

SIR

95% CI

Stomach

401

60.4 ± 11.1

1.83

1.65

2.01

10

62.0 ± 8.6

5.55

2.64

10.25

Colorectum

7233

61.5 ± 11.6

1.70

1.66

1.74

417

60.0 ± 12.0

2.76

2.51

3.04

 Colon

3309

61.4 ± 11.6

1.84

1.78

1.90

153

59.3 ± 12.6

3.64

3.08

4.26

 Rectum

1037

61.4 ± 10.4

1.64

1.54

1.74

17

59.2 ± 12.8

2.20

1.28

3.52

Pancreas

455

62.5 ± 10.0

2.04

1.86

2.24

10

53.1 ± 14.6

4.96

2.36

9.15

Lung

4122

62.6 ± 9.0

2.11

2.05

2.17

169

62.2 ± 8.8

3.42

2.93

3.98

Breast

15,805

55.0 ± 10.7

1.74

1.71

1.76

913

55.4 ± 10.7

2.50

2.34

2.67

Endometrium

799

59.5 ± 9.7

1.90

1.77

2.03

22

57.3 ± 9.0

5.58

3.49

8.46

Ovary

481

53.3 ± 10.8

2.32

2.12

2.54

14

51.6 ± 8.4

8.99

4.90

15.13

Prostate

21,688

64.4 ± 6.9

2.20

2.17

2.23

2550

63.5 ± 6.7

3.74

3.60

3.89

Kidney parenchyma

319

58.4 ± 10.8

1.94

1.73

2.16

6

34.5 ± 5.5

5.17

1.86

11.33

Bladder

1294

62.4 ± 10.5

1.82

1.72

1.92

25

63.0 ± 9.9

2.48

1.60

3.67

Melanoma

2620

51.3 ± 14.0

2.41

2.32

2.50

95

48.3 ± 14.4

5.68

4.59

6.94

Skin

1417

65.0 ± 10.2

1.96

1.86

2.06

59

65.7 ± 9.2

4.60

3.50

5.94

Nervous system

763

51.1 ± 14.6

1.55

1.44

1.67

27

39.3 ± 13.9

6.24

4.11

9.09

Endocrine glands

325

49.2 ± 14.0

2.02

1.81

2.26

16

46.9 ± 13.3

14.82

8.45

24.11

Non-Hodgkins lymphoma

737

58.5 ± 12.0

1.71

1.59

1.84

6

57.7 ± 12.6

1.51

0.54

3.31

Leukemia

626

59.3 ± 12.3

1.88

1.73

2.03

17

59.8 ± 7.3

5.03

2.92

8.06

All above

63,431

60.2 ± 10.8

1.93

1.92

1.95

4526

60.7 ± 9.9

3.33

3.23

3.43

  1. O Observed, SIR Standardized incidence ratio, CI Confidence intervals