From: Are population level familial risks and germline genetics meeting each other?
One family member diagnosed with concordant cancer | Two or more family members diagnosed with concordant cancer | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
Cancer site | O | Mean age ± SD | SIR | 95% CI | O | Mean age ± SD | SIR | 95% CI | ||
Stomach | 401 | 60.4 ± 11.1 | 1.83 | 1.65 | 2.01 | 10 | 62.0 ± 8.6 | 5.55 | 2.64 | 10.25 |
Colorectum | 7233 | 61.5 ± 11.6 | 1.70 | 1.66 | 1.74 | 417 | 60.0 ± 12.0 | 2.76 | 2.51 | 3.04 |
Colon | 3309 | 61.4 ± 11.6 | 1.84 | 1.78 | 1.90 | 153 | 59.3 ± 12.6 | 3.64 | 3.08 | 4.26 |
Rectum | 1037 | 61.4 ± 10.4 | 1.64 | 1.54 | 1.74 | 17 | 59.2 ± 12.8 | 2.20 | 1.28 | 3.52 |
Pancreas | 455 | 62.5 ± 10.0 | 2.04 | 1.86 | 2.24 | 10 | 53.1 ± 14.6 | 4.96 | 2.36 | 9.15 |
Lung | 4122 | 62.6 ± 9.0 | 2.11 | 2.05 | 2.17 | 169 | 62.2 ± 8.8 | 3.42 | 2.93 | 3.98 |
Breast | 15,805 | 55.0 ± 10.7 | 1.74 | 1.71 | 1.76 | 913 | 55.4 ± 10.7 | 2.50 | 2.34 | 2.67 |
Endometrium | 799 | 59.5 ± 9.7 | 1.90 | 1.77 | 2.03 | 22 | 57.3 ± 9.0 | 5.58 | 3.49 | 8.46 |
Ovary | 481 | 53.3 ± 10.8 | 2.32 | 2.12 | 2.54 | 14 | 51.6 ± 8.4 | 8.99 | 4.90 | 15.13 |
Prostate | 21,688 | 64.4 ± 6.9 | 2.20 | 2.17 | 2.23 | 2550 | 63.5 ± 6.7 | 3.74 | 3.60 | 3.89 |
Kidney parenchyma | 319 | 58.4 ± 10.8 | 1.94 | 1.73 | 2.16 | 6 | 34.5 ± 5.5 | 5.17 | 1.86 | 11.33 |
Bladder | 1294 | 62.4 ± 10.5 | 1.82 | 1.72 | 1.92 | 25 | 63.0 ± 9.9 | 2.48 | 1.60 | 3.67 |
Melanoma | 2620 | 51.3 ± 14.0 | 2.41 | 2.32 | 2.50 | 95 | 48.3 ± 14.4 | 5.68 | 4.59 | 6.94 |
Skin | 1417 | 65.0 ± 10.2 | 1.96 | 1.86 | 2.06 | 59 | 65.7 ± 9.2 | 4.60 | 3.50 | 5.94 |
Nervous system | 763 | 51.1 ± 14.6 | 1.55 | 1.44 | 1.67 | 27 | 39.3 ± 13.9 | 6.24 | 4.11 | 9.09 |
Endocrine glands | 325 | 49.2 ± 14.0 | 2.02 | 1.81 | 2.26 | 16 | 46.9 ± 13.3 | 14.82 | 8.45 | 24.11 |
Non-Hodgkins lymphoma | 737 | 58.5 ± 12.0 | 1.71 | 1.59 | 1.84 | 6 | 57.7 ± 12.6 | 1.51 | 0.54 | 3.31 |
Leukemia | 626 | 59.3 ± 12.3 | 1.88 | 1.73 | 2.03 | 17 | 59.8 ± 7.3 | 5.03 | 2.92 | 8.06 |
All above | 63,431 | 60.2 ± 10.8 | 1.93 | 1.92 | 1.95 | 4526 | 60.7 ± 9.9 | 3.33 | 3.23 | 3.43 |