Are population level familial risks and germline genetics meeting each other?

Table 1 Number of cancers, median ages, incidence rates, and number of familial cancer in the 20 to 84 year old index population (N = 9,338,882) during 1958–2016. Modified from ref. [9]

	Total numbers^a			Family history of concordant cancer
Cancer site	No	%	Median age	No	Familial proportion %	Median age
Lip	5772	1.1	60	119	2.1	61
Salivary gland	1299	0.2	53	3	0.2	49
Pharynx	3718	0.7	58	45	1.2	59
Esophagus	3854	0.7	63	73	1.9	63
Stomach	6980	1.3	61	411	5.9	62
Small intestine	2442	0.5	60	54	2.2	62
Colorectum	48,803	9.3	63	7650	15.7	63
Colon	30,819	5.9	64	3462	11.2	63
Rectum	17,984	3.4	62	1054	5.9	63
Liver, primary	4113	0.8	63	86	2.1	63
Pancreas	9557	1.8	64	465	4.9	63
Lung	33,121	6.3	64	4291	13.0	63
Breast	95,756	18.2	55	16,718	17.5	55
Cervix	10,542	2.0	40	223	2.1	39
Endometrium	16,012	3.0	61	821	5.1	60
Ovary	11,554	2.2	55	495	4.3	53
Prostate	91,696	17.5	66	24,238	26.4	65
Testis	8272	1.6	33	158	1.9	33
Kidney	8574	1.6	60	325	3.8	59
Bladder	18,738	3.6	64	1319	7.0	64
Melanoma	37,842	7.2	52	2715	7.2	52
Skin	19,014	3.6	67	1476	7.8	66
Eye	1607	0.3	57	10	0.6	58
Nervous system	21,560	4.1	51	790	3.7	52
Thyroid gland, adenocarcinoma	6044	1.2	42	136	2.3	41
Endocrine glands	11,713	2.2	53	341	2.9	50
Bone	1186	0.2	39	9	0.8	42
Connective tissue	3754	0.7	52	34	0.9	52
Hodgkins disease	4064	0.8	32	57	1.4	36
Non-Hodgkins lymphoma	17,197	3.3	59	743	4.3	60
Myeloma	5618	1.1	63	140	2.5	63
Leukemia	14,617	2.8	60	643	4.4	61
All above	525,019	100.0	60	69,104	13.2	62

^aTotal number of cancers was 552,953 including 27,934 diverse rare cancers, which were not included in this study.

ISSN: 1897-4287