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Table 3 HADS anxiety and depression levels over time. Scores < 8: inconspicuous/non-case; scores ≥8: borderline cases of anxiety/depression. T0: at baseline (before genetic test result disclosure), T1: 6–8 weeks after genetic test result disclosure, T2: 6–8 months after genetic test result disclosure

From: Psychological factors and the uptake of preventative measures in BRCA1/2 pathogenic variant carriers: results of a prospective cohort study

T0

Total

RRM group

IBS group

p -value

 

N

%

N

%

N

%

 
 

97

100

33

33.3%

64

66.7%

 

Anxiety

 M (SD)

6.3 (4.1)

7.6 (4.6)

5.7 (3.7)

.03

 <  8

56

57.7%

22

39.3%

34

60.7%

.201

 ≥ 8

41

42.3%

11

26.8%

30

73.2%

Depression

 M (SD)

2.7 (2.7)

 

3.1 (2.5)

 

2.5 (2.8)

 

.32

T1

Total

RRM group

IBS group

p -value

 

N

%

N

%

N

%

 
 

96

100%

32

33.3%

64

66.7%

 

Anxiety

 M (SD)

6.9 (4.1)

8.2 (4.4)

6.2 (3.9)

.03

 <  8

60

62.5%

16

26.7%

44

73.3%

.075

 ≥ 8

36

37.5%

16

44.4%

20

55.6%

Depression

 M (SD)

3.2 (3.2)

 

3.2 (3.0)

 

3.2 (3.3)

 

.95

T2

Total

RRM group

IBS group

p -value

 

N

%

N

%

N

%

 
 

97

100%

33

33.3%

 

66.7%

 

Anxiety

 M (SD)

6.3 (3.8)

5.7 (3.9)

6.6 (3.8)

.27

 <  8

56

57.7%

22

39.3%

34

60.7%

.201

 ≥ 8

41

42.3%

11

26.8%

30

73.2%

Depression

 M (SD)

3.0 (3.0)

 

2.2 (3.0)

 

3.4 (3.2)

 

.05

  1. Abbreviations: M Mean, SD Standard deviation, RRM Risk-reducing mastectomy, IBS Intensified breast surveillance
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Hereditary Cancer in Clinical Practice

ISSN: 1897-4287