Psychological factors and the uptake of preventative measures in BRCA1/2 pathogenic variant carriers: results of a prospective cohort study

Table 2 Cohort sample characteristics of study participants that returned questionnaires at all three time points.

	Total		RRM group		IBS group		p -value
	N	%	n	%	n	%	p -value
Total	97^a	100	33	33.3	64	66.7
Age (n = 97)
≤ 29	14	14.4	5	35.7	9	64.3	.911
30–39	21	21.6	6	28.6	15	71.4
40–49	40	41.2	15	37.5	25	62.5
50–59	17	17.5	6	35.3	11	64.7
≥ 60	5	5.2	1	20.0	4	80.0
Educational level (n = 96)
Low/intermediate	48	50.0	12	25.0	36	75.0	.083
High/university	48	50.0	20	41.7	28	58.3	.083
Children (n = 93)
Yes	59	63.4	22	37.3	37	62.7	.287
No	34	36.6	9	26.5	25	73.5	.287
Marital status (n = 95)
Married or in relationship	69	72.6	25	36.2	44	63.8	.392
Single	26	27.4	7	26.9	19	73.1	.392
BC diagnosis (n = 97)
Yes	57	58.8	19	33.3	38	66.7	.865
No	40	41.2	14	35.0	26	65.0	.865
Mother affected by or died from BC (n = 97)
Yes	56	57.7	21	37.5	35	62.5	.398
No	41	42.3	12	29.3	29	70.7	.398
Sister affected by or died from BC (n = 97)
Yes	32	33.0	11	34.4	21	65.6	.959
No	65	67.0	22	33.8	43	66.2	.959
Grandmother affected by or died from BC (n = 97)
Yes	27	27.8	8	29.6	19	70.4	.571
No	70	72.2	25	35.7	45	64.3	.571
Aged < 20 when family member died from BC (n = 97)
Yes	22	22.7	6	27.3	16	72.7	.447
No	75	77.3	27	36.0	48	64.0	.447
Statistical 5-year BC risk (BOADICEA) at T1 (n = 92)
Mean			10.0%		9.8%		.813
SD			4.0		4.5		.813
Lifetime BC risk perception at T1 (n = 54)
Mean			68.1%		55.3%		.180
SD			33.9		25.9		.180
5-year BC risk perception T2 (n = 94)
Mean			9.1%		28.2%		<.001
SD			12.8%		24.8%		<.001

Abbreviations: SD Standard deviation, RRM Risk-reducing mastectomy, IBS Intensified breast surveillance, BC Breast cancer, BOADICEA Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm, CI Confidence interval
^aMissing value: 1

ISSN: 1897-4287