Mainstream genetic testing for women with ovarian cancer provides a solid basis for patients to make a well-informed decision about genetic testing

Table 2 Patient characteristics

	Intervention group, n = 105	Control group, n = 91	P-value
Age at diagnosis, mean (sd)	67.4 (9.6)	63.0 (11.1)	0.003*
Newly diagnosed at time of being offered genetic testing^a, n (%)	91 (86.7)	62 (68.1)	0.002*
Histology, n (%)	78 (74.3)	64 (70.3)	0.183
- Serous,	- 72	- 51
- high grade	- 5	- 6
- low grade	- 1	- 7
- grade unknown	5 (4.8)	6 (6.6)
- Endometrioid clear cell	5 (4.8)	4 (4.4)
- Mucinous	8 (7.6)	7 (7.7)
- Other/unknown	9 (8.6)	10 (11.0)
DNA test results, n (%)
- Normal	95 (90.5)	74 (81.3)	0.068
- Pathogenic variant or variant of unknown significance	10 (9.5)	17 (18.7)	0.068
Children, n (%)
- No	12 (11.4)	20 (22.0)	0.038*
- Yes	92 (87.6)	67 (73.6)
- Unknown	1 (1.0)	4 (4.4)
Educational level^b, n (%)
- Low	9 (8.6)	9 (9.9)	0.851
- Intermediate	71 (67.6)	58 (63.7)
- High	24 (22.9)	23 (25.3)
- Unknown	1 (1.0)	1 (1.1)
Migrant status^c, n (%)
- Dutch Native	92 (87.6)	82 (90.1)	0.946
- Migrant	10 (9.5)	8 (8.8)
- Western	- 8	- 6
- Non-Western	- 2	- 2
- Unknown	3 (2.9)	1 (1.1)
Personal history of another type of cancer, n (%)	16 (15.7)	15 (17.2)	0.774

^a Newly diagnosed at time of being offered genetic testing was defined as receiving pre-test counseling ≤ 6 months after diagnosis for the intervention group and being referred to the genetics department ≤ 6 months after diagnosis for the control group
^b Educational level is subdivided into low, intermediate or high level as categorized by the Dutch Standard Classification of Education 2021 [31]. Low level education is no education, primary education or lower secondary education, intermediate level education is upper secondary education and high-level education is tertiary education
^c Migrant status is defined by Statistics Netherlands (CBS) as having at least one parent who was born abroad [32]. A distinction can be made between a Western migration background (country of origin in Europe (excluding Turkey), North America, and Oceania, or from Indonesia or Japan) and a non-Western migration background (country of origin in Africa, South America or Asia (excluding Indonesia and Japan) or from Turkey). If a person is born in the Netherlands, the migration background is determined by the mother’s country of birth. When the mother is born in the Netherlands as well, then the migration background is determined by the father’s country of birth
^*p ≤ 0.05

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