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Table 5 Odds Ratios and 95% Confidence intervals for receiving one or more HBOC, lynch syndrome, tier 2 molecular pathology procedures, and any cancer genetic testing

From: Statewide trends and factors associated with genetic testing for hereditary cancer risk in Arkansas 2013–2018

Variable

HBOC

Odds Ratio (95% CI)

HBOC (female-only sample) Odds Ratio (95% CI)

Lynch Syndrome

Odds Ratio (95% CI)

General Genetic Testinga

Odds Ratio (95% CI)

Any Cancer Genetic Testingb

Odds Ratio (95% CI)

Age

1.24 (1.20, 1.28)

1.25 (1.21, 1.29)

1.22 (1.12, 1.36)

1.04 (1.03, 1.06)

1.06 (1.04, 1.07)

Age (Squared)

1.00 (1.00, 1.00)

1.00 (1.00, 1.00)

1.00 (1.00, 1.00)

1.00 (1.00, 1.00)

1.00 (1.00, 1.00)

Modified Elixhauser Index

1.08 (1.05, 1.12)

1.07 (1.03, 1.10)

1.12 (1.03, 1.20)

1.13 (1.12, 1.14)

1.13 (1.12, 1.14)

Sex (reference = Male) Female

18.91 (13.01, 28.86)

-------

1.93 (1.11, 3.51)

0.90 (0.83, 0.99)

1.22 (1.12, 1.32)

Health Plan (reference = Commercial)

 State employee

1.65 (1.37, 1.97)

1.64 (1.36, 1.97)

1.66 (0.77, 3.34)

4.54 (3.94, 5.23)

2.66 (2.35, 3.00)

 Medicaid

0.24 (0.18, 0.32)

0.22 (0.17, 0.30)

0.78 (0.36, 1.58)

0.52 (0.43, 0.64)

0.33 (0.28, 0.40)

 Medicare

0.41 (0.30, 0.56)

0.38 (0.27, 0.52)

0.86 (0.41, 1.74)

3.93 (3.45, 4.50)

2.42 (2.16, 2.71)

 State Region (reference = Northwest)

 

0.43 (0.31, 0.57)

0.63 (0.26, 1.53)

0.85 (0.72, 1.01)

0.79 (0.68, 0.91)

 West

0.42 (0.31, 0.56)

    

 East

0.70 (0.57, 0.88)

0.69 (0.56, 0.87)

0.62 (0.28, 1.39)

0.83 (0.71, 0.97)

0.83 (0.72, 0.95)

 Central

0.66 (0.52, 0.84)

0.66 (0.52, 0.84)

0.37 (0.13, 0.93)

1.11 (0.95, 1.29)

1.01 (0.88, 1.17)

 Northeast

0.28 (0.15, 0.36)

0.23 (0.14, 0.36)

0.30 (0.06, 1.05)

0.72 (0.58, 0.88)

0.64 (0.53, 0.77)

 North Central

0.59 (0.43, 0.80)

0.56 (0.40, 0.77)

1.47 (0.66, 3.38)

0.51 (0.41, 0.63)

0.54 (0.45, 0.65)

 Midwest

0.42 (0.30, 0.57)

0.41 (0.30, 0.57)

0.69 (0.26, 1.76)

1.20 (1.02, 1.42)

1.07 (0.92, 1.27)

 Any Nicotine Usage (reference = No)

0.88 (0.70, 1.11)

0.90 (0.71, 1.13)

1.05 (0.54, 1.95)

1.07 (0.95, 1.20)

1.01 (0.90, 1.12)

 Developmental Disorders (reference = No)

0.85 (0.28, 1.92)

0.97 (0.32, 2.20)

0.43 (0.00, 3.09)

1.11 (0.84, 1.44)

1.12 (0.86, 1.44)

 Anxiety Disorders (referent = No)

1.19 (0.99, 1.43)

1.22 (1.01, 1.47)

1.37 (0.75, 2.45)

1.61 (1.45, 1.78)

1.54 (1.40, 1.67)

 Other Mental Disorders (reference = No)

1.53 (1.15, 2.00)

1.56 (1.17, 2.05)

4.36 (2.28, 7.98)

1.60 (1.39, 1.83)

1.59 (1.40, 1.80)

 Model c-statistic

0.88

0.81

0.82

0.82

0.79

 Model Brier score

<0.001

<0.001

<0.001

0.003

0.003

  1. HBOC Hereditary Breast and Ovarian Cancer
  2. a Tier 2 molecular pathology procedures are based on the complexity of the testing technique and are not specific to a gene or hereditary cancer syndrome
  3. b Any cancer genetic testing included tests in the HBOC, Lynch syndrome, Tier 2 molecular pathology procedures, and other hereditary cancer syndrome (HCS) panel categories