Hereditary Cancer in Clinical Practice

Table 4 Summary of the main recommendations on screening for PC (AISP, CAPS, AGA) [66, 90, 91]

From: Current status of inherited pancreatic cancer

	CAPS	AGA	AISP
Target population
PJS (LKB1/STK11)	+	+	+
FAMMM (CDKN2A)	+	+	+
HBOC (BRCA1, BRCA2, PALB2)	+	+	+
LS (MLH1, MSH2, or MSH6)	+	+	+
AT (ATM)	+	+	–
FPC	+	+	+
HP (PRSS1, SPINK1, PRSS2)	?	+	+
The onset of screening (patients’ age)
PJS	40	35	30
FAMMM	40	40	30
HBOC	45 or 55^a	50^a	40^b
LS	45 or 55^a	50^a	40^b
AT	45 or 55^a	50^a	–
FPC	50 or 55^a	50^a	45^a
HP	–	40	40^b
Method of screening
MRI/MRCP	+	+	+
EUS	+	+	+
HbA1c	+
Intervals
If no abnormality	12 M	12 M	12 M
If abnormality	3 or 6 M	3 or 6 M	Mf

Abbreviations
CAPS- Cancer of the Pancreas Surveillance Consortium
AGA American Gastroenterological Association
AISP Italian Association for the Study of the Pancreas AISP
PJS Peutz -Jeghers syndrome
FAMMM Familial atypical multiple mole melanoma
HBOC Hereditary breast-ovarian cancer syndrome
LS Lynch syndrome
AT Ataxia-teleangiectasia syndrome
HP Hereditary pancreatitis
FPC Familial pancreatic cancer
M Months
Mf More frequently in high-risk patients
^a 10 years less than age of the youngest affected family member
^b 5 years less than age of the youngest affected family member

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ISSN: 1897-4287

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