Table 2 Loci associated with the risk of development of PC [80,81,82,83,84]
Chromosome | Gene | SNP | Odds ratio (95% CI) | P value |
|---|---|---|---|---|
Caucasians | ||||
16q23.1 | BCAR1/CTRB1/CTRB2 | rs7190458 | 1.46 (1.3–1.65) | 1.1 × 10− 10 |
1p36.33 | NOC2L | rs13303010 | 1.26 (1.19–1.35) | 8.00 × 10−14 |
7q32.3 | LINC-PINT | rs6971499 | 0.79 (0.74–0.84) | 3.00 × 10− 12 |
1q32.1 | NR5A2 | rs3790844 | 0.77 (0.71–0.84) | 2.45 × 10− 10 |
Asians | ||||
2p24.1 | APOB | rs183117027 | 2.34 (1.72–3.16) | 4.21 × 10−08 |
8p21.3 | DOK2 | rs2242241 | 1.85 (1.50–2.27) | 4.34 × 10−09 |
19p13.12 | PKN1 | rs34309238 | 1.77 (1.48–2.12) | 5.25 × 10−10 |
16p12.3 | GP2 | rs78193826 | 1.46 (1.29–1.66) | 4.29 × 10−09 |