Table 1 European registry of hereditary pancreatitis and familial pancreatic cancer criteria [6]
EUROPAC criteria | |
|---|---|
Criterion 1 | ≥2 first-degree relatives with PC |
Criterion 2 | ≥ 3 relatives with pancreatic cancer |
Criterion 3 | Possible associated cancer syndrome (defined as sub-criteria below) in addition to the case of PC being studied |
Criterion 3.a: HBOC | Personal/family history (≥1 first/second-degree relatives) of breast/ovarian cancer |
Criterion 3.b: FAMMM | Personal/family history of melanoma in ≥1 first/second degree relative AND a high total body naevi count (often > 50) |
Criterion 3.c: LS | Personal/family history (≥1 first/second-degree relatives) of a LS-associated cancer (such as colorectal, endometrial, small bowel, renal) |
Criterion 3.d: PJS | Oral/mucous membrane pigmentation +/− a personal/family history (≥1 first/second-degree relatives) of gastrointestinal cancers in first/second |