Table 4 Multiple linear regression models to identify variables associated with MICRA scores

From: Reflex BRCA1 and BRCA2 tumour genetic testing for high-grade serous ovarian cancer: streamlined for clinicians but what do patients think?

	Distress		Uncertainty		Total Score
	B (95% CI)	p-value	B (95% CI)	p-value	B (95% CI)	p-value
Block 1
Dispositional	−0.29 (− 0.60, − 0.02)	0.06	−0.65 (− 0.98, − 0.31)	< 0.001	− 1.21 (− 1.88, − 0.53)	< 0.001
optimism	− 0.10 (− 0.26, 0.06)	0.20	− 0.36 (− 0.53, − 0.18)	< 0.001	− 0.45 (− 0.79, − 0.10)	0.01
Age at diagnosis	2.32 (− 0.95, 5.59)	0.16	5.05 (1.44, 8.66)	0.01	7.04 (0.14, 14.22)	0.05
Children	0.98 (− 2.56, 4.52)	0.58	1.10 (− 2.81, 5.01)	0.57	4.26 (− 3.52, 12.04)	0.28
PV present in tumour	3.70 (0.22, 7.17)	0.04	2.70 (− 1.13, 6.54)	0.16	3.92 (− 3.71, 11.56)	0.31
Primary surgery	R²_adj = 0.172		R²_adj = 0.427		R²_adj = 0.308
Block 2
Dispositional	−0.09 (− 0.40, 0.22)	0.55	−0.35 (− 0.66, − 0.04)	0.03	− 0.73 (− 1.39, − 0.06)	0.03
optimism	− 0.005 (− 0.16, 0.15)	0.95	− 0.21 (− 0.37, − 0.05)	0.01	− 0.21 (− 0.55, 0.13)	0.21
Age at diagnosis	1.19 (− 1.91, 4.29)	0.45	3.38 (− 0.23, 6.52)	0.04	4.33 (− 2.35, 11.01)	0.20
Children	2.16 (− 1.20, 5.51)	0.20	2.85 (0.55, 6.27)	0.10	7.09 (1.14, 14.32)	0.05
PV present in tumour	2.86 (− 0.40, 6.11)	0.08	1.46 (− 1.85, 4.76)	0.38	1.91 (− 5.11, 8.92)	0.59
Primary surgery	0.21 (0.08, 0.33)	0.002	0.31 (0.18, 0.44)	< 0.001	0.50 (0.22, 0.77)	< 0.001
Cancer-related distress	R²_adj = 0.293		R²_adj = 0.587		R²_adj = 0.431

PV pathogenic or likely pathogenic variant
Multiple linear regression model for the subset of participants who completed the MICRA questionnaire (n = 63)

Back to article page