Table 5 NRG1 variants associated with hereditary thyroid cancer
From: Genetic susceptibility to hereditary non-medullary thyroid cancer
NRG1 variant | Annotation | Odds ratio | P-value | Type of thyroid cancer | population | Reference |
|---|---|---|---|---|---|---|
rs2439302 | Intron variant | 1.36 | 2.0 × 10− 9 | NMTC | Icelandic | Gudmundsson et al. (2012) [27] |
1.41 | 2.78 × 10− 5 | PTC | Chinese | Wang et al. (2013) [67] | ||
1.27 | 0.003 | PTC | Japanese | Rogounovitch et al. (2015) [63] | ||
1.46 | 4.0 × 10− 5 | PTC | Kazakh | Mussazhanova et al. (2020) [168] | ||
1.59 | 2.45 × 10− 5 | PTC | Ohio | Liyanarachchi et al. (2013) [70] | ||
1.23 | 9.29 × 10− 4 | PTC | Poland | Liyanarachchi et al. (2013) [70] | ||
rs2466076 | Intron variant | 1.32 | 1.5 × 10− 17 | NMTC | Icelandic | Gudmundsson et al. (2017) [28] |
rs6996585 | Intron variant | 1.43 | 9.0 × 10− 12 | PTC | Korean | Son et al. (2017) [29] |
rs12542743 | Intron variant | 1.39 | 1.01 × 10− 10 | PTC | Korean | Son et al. (2017) [29] |
rs2439304 | Promoter variant | 1.2 | 0.001 | DTC | Europeans, Melanesians and Polynesians | Guibon et al. (2021) [74] |