Table 4 TITF1/NKX2.1 variant rs944289 associated with hereditary thyroid cancer
From: Genetic susceptibility to hereditary non-medullary thyroid cancer
TITF1/NKX2.1 variant | Annotation | Odds ratio | P-value | Type of thyroid cancer | population | Reference |
|---|---|---|---|---|---|---|
rs944289 | NA | 1.37 | 2.0 × 10−9 | NMTC | Iceland, Columbus, Spain | Gudmundsson et al. (2009) [35] |
1.23 | 0.002 | PTC | northern Chinese Han populations | Zhang et al. (2020) [59] | ||
1.24 | 0.0014 | DTC | Korean | Son et al. (2017) [29] | ||
1.24 | 1.5 × 10− 5 | NMTC | Spain and Southern Europe | Mancikova et al. (2015) [33] | ||
1.21 | 0.0121 | Sporadic PTC | Japanese | Matsuse et al. (2011) [68] | ||
1.53 | 2.2 × 10− 10 | PTC | Chinese | Wang et al. (2013) [67] | ||
1.23 | 0.003 | PTC | Japanese | Rogounovitch et al. (2015) [63] | ||
rs368187 | exon variant | 1.39 | 5.1 × 10− 23 | NMTC | European ancestry | Gudmundsson et al. (2017) [28] |
rs34081947 | NA | 1.27 | 1.2 × 10− 7 | DTC | Korean | Son et al. (2017) [29] |