Table 2 FOXE1 variants associated with hereditary thyroid cancer
From: Genetic susceptibility to hereditary non-medullary thyroid cancer
FOXE1 variant | Annotation | Odds ratio* | P-value | Type of thyroid cancer | Population | Reference |
|---|---|---|---|---|---|---|
rs965513 | Intron variant | 1.75 | 1.7 × 10− 27 | NMTC | Iceland, Columbus, Spain | Gudmundsson et al. (2009) [35] |
2.81 | <  0.0001 | Sporadic NMTC | Portuguese | Tomaz et al. (2012) [37] | ||
2.30 | 0.0002 | Familial NMTC | ||||
1.98 Additive Model | 0.0045 | Familial NMTC | NA | Bonora et al. (2014) [39] | ||
5.10 Recessive Model | 0.00043 | Familial NMTC | ||||
1.66 | 4.48 × 10− 10 | PTC | Korean | Son et al. (2017) [29] | ||
1.587 | 4.2 × 10− 4 | PTC | Japanese | Rogounovitch et al. (2015) [63] | ||
1.53 | 1.4 × 10− 4 | PTC | Chinese | Wang et al. (2013) [67] | ||
1.65 | 4.8 × 10− 12 | Radiation-related PTC | Belarus | Takahashi et al. (2010) [167] | ||
1.69 | 1.3 × 10− 4 | Sporadic PTC | Japanese | Matsuse et al. (2011) [68] | ||
rs7849497 | 5 prime UTR variant | 2.14 | 0.0001 | Familial + sporadic NMTC | Portuguese | Tomaz et al. (2012) [37] |
rs1867278 | 5 prime UTR variant | 1.7 | 0.0022 | Familial + sporadic NMTC | Portuguese | Tomaz et al. (2012) [37] |
rs1867279 | 5 prime UTR variant | 2.17 | < 0.0001 | Familial + sporadic NMTC | Portuguese | Tomaz et al. (2012) [37] |
rs1867280 | 5 prime UTR variant | 1.62 | 0.0052 | Familial + sporadic NMTC | Portuguese | Tomaz et al. (2012) [37] |
rs1867277 | 5 prime UTR variant | 1.70 | 0.0022 | Familial + sporadic NMTC | Portuguese | Tomaz et al. (2012) [37] |
1.49 | 5.9 × 10− 9 | PTC | Spanish and Italian | Landa et al. (2009) [36] | ||
3.17 Recessive Model | 0.0013 | Familial NMTC | NA | Bonora et al. (2014) [39] | ||
rs3021523 | Synonymous variant | 2.04 | 0.0002 | Familial + sporadic NMTC | Portuguese | Tomaz et al. (2012) [37] |
rs10759944 | Intron Variant | 4.63 Recessive Model | 0.00094 | Familial NMTC | NA | Bonora et al. (2014) [39] |
2.06 Additive Model | 0.0031 | Familial NMTC | NA | Bonora et al. (2014) [39] | ||
rs7037324 | Non-coding transcript variant | 1.54 | 1.2 × 10− 17 | NMTC | Spain and Southern Europe | Mancikova et al. (2015) [33] |
rs7028661 | Intron variant | 1.64 | 1.0 × 10− 2 | NMTC | Spain and Southern Europe | Mancikova et al. (2015) [33] |
1.56 | 1.64 × 10− 8 | PTC | Korean | Son et al. (2017) [29] | ||
rs1588635 | 78 kb 5′ of FOXE1 | 1.57 | 1.30 × 10− 8 | PTC | Korean | Son et al. (2017) [29] |
rs10122541 | NA | 1.54 | 1.1 × 10− 17 | NMTC | Spain and Southern Europe | Mancikova et al. (2015) [33] |
rs3021526 | Exon variant | 1.85 | 0.0004 | Familial + sporadic NMTC | Portuguese | Tomaz et al. (2012) [37] |
PolyAla | PolyAla tract expansions (> 14 alanines) | 2.49 | < 0.0001 | Familial + sporadic NMTC | Portuguese | Tomaz et al. (2012) [37] |