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Table 1 Variants associated with increased risk for non-medullary thyroid cancer in various populations identified by GWAS

From: Genetic susceptibility to hereditary non-medullary thyroid cancer

Genes

Chr.

Reference

variant

Population

Type of tumoura

OR

P value

MBIP

14q13.3

Gudmundsson et al. (2012) [27]

rs116909374

Iceland

NMTC

2.09

4.6 × 10−11

Gudmundsson et al. (2017) [28]

rs116909374

European ancestry

NMTC

1.81

1.1 × 10− 16

Son et al. (2017) [29]

rs34081947

Korean

PTC

1.28

2.4 × 10− 4

Son et al. (2017) [29]

rs944289

Korean

PTC

1.24

1.41 × 10− 3

PCNLX2

1q42.2

Gudmundsson et al. (2017) [28]

rs12129938

Iceland, Spain, United States, Netherlands

NMTC

1.32

4.0 × 10− 11

LRRC34, TERC

3q26.2

Gudmundsson et al. (2017) [28]

rs6793295

Iceland, Spain, United States, Netherlands

NMTC

1.23

2.7 × 10− 8

TERT

5p15.33

Gudmundsson et al. (2017) [28]

rs10069690

Iceland, Spain, United States, Netherlands

NMTC

1.20

3.2 × 10− 7

EPB41L4A, NREP

5q22.1

Gudmundsson et al. (2017) [28]

rs73227498

Iceland, Spain, United States, Netherlands

NMTC

1.37

3.0 × 10− 10

OBFC1

10q24.33

Gudmundsson et al. (2017) [28]

rs7902587

Iceland, Spain, United States, Netherlands

NMTC

1.41

5.4 × 10− 11

SMAD3

15q22.33

Gudmundsson et al. (2017) [28]

rs2289261

Iceland, Spain, United States, Netherlands

NMTC

1.23

3.1 × 10− 9

IMMP2L

7q31.1

Köhler et al. (2013) [30]

rs10238549

Italy

DTC

1.27

4.1 × 10− 6

Köhler et al. (2013) [30]

rs7800391

Italy

DTC

1.25

5.7 × 10− 6

RARRES1

3q25.32

Köhler et al. (2013) [30]

rs7617304

Italy

DTC

1.25

4.6 × 10− 5

SNAPC4

9q34.3

Köhler et al. (2013) [30]

rs10781500

Italy

DTC

1.23

3.5 × 10− 5

PLAU

10q22.2

Köhler et al. (2013) [30]

rs2633322

Italy

DTC

1.21

5.3 × 10− 3

SNX19

11q24.3-q25

Köhler et al. (2013) [30]

rs11823005

Italy

DTC

1.35

1.7 × 10− 3

GTSCR1

18q22.2

Köhler et al. (2013) [30]

rs9951245

Italy

DTC

1.20

9.8 × 10− 4

BATF

14q24.3

Figlioli et al. (2014) [31]

rs10136427

Italy

DTC

1.40

4.4 × 10− 7

DHX35

20q11.23-q12

Figlioli et al. (2014) [31]

rs7267944

Italy

DTC

1.39

2.1 × 10− 8

ARSB

5q14.1

Figlioli et al. (2014) [31]

rs13184587

Italy

DTC

1.28

8.5 × 10− 6

SPATA13

13q12.12

Figlioli et al. (2014) [31]

rs1220597

Italy

DTC

1.26

3.3 × 10− 6

GPD1L

3p22.3

Figlioli et al. (2014) [31]

rs1159444

Italian, Polish, Spanish

DTC

1.23

9.13 × 10− 4

TIPRL

1q24.2

Figlioli et al. (2014) [31]

rs2281016

Italian, Polish, Spanish

DTC

1.16

2.0 × 10− 3

DACH1

13q21.33

Figlioli et al. (2014) [31]

rs2245026

Italian, Polish, Spanish

DTC

1.17

2.0 × 10− 3

GALNTL4

11p15.4

Figlioli et al. (2015) [32]

rs7935113

Italian

DTC

1.36

7.4 × 10− 7

FOXA2

20p11.21

Figlioli et al. (2015) [32]

rs1203952

Italian

DTC

1.29

4.4 × 10− 6

CAMTA1

1p36.31-p36.23

Figlioli et al. (2015) [32]

rs10864251

Italian

DTC

1.17

1.40 × 10− 3

Figlioli et al. (2015) [32]

rs4908581

Italian

DTC

1.22

4.61 × 10− 5

LOC728241

2

Figlioli et al. (2015) [32]

rs1400967

Italian

DTC

1.22

7.11 × 10− 4

C3orf63

3p14.3

Figlioli et al. (2015) [32]

rs11130536

Italian

DTC

1.24

3.27 × 10− 4

PDZRN3

3p13

Figlioli et al. (2015) [32]

rs3863973

Italian

DTC

1.22

5.95 × 10− 4

SYK

9q22.2

Figlioli et al. (2015) [32]

rs290212

Italian

DTC

1.23

6.84 × 10− 5

C14orf147

14q13.1

Figlioli et al. (2015) [32]

rs4624074

Italian

DTC

1.20

1.46 × 10− 4

WDR11-AS1

10q26.12

Mancikova et al. (2015) [33]

rs2997312

Southern European

NMTC

1.35

1.2 × 10− 4

Mancikova et al. (2015) [33]

rs10788123

Southern European

NMTC

1.26

5.2 × 10− 4

Mancikova et al. (2015) [33]

rs1254167

Southern Europea

NMTC

1.38

5.9 × 10− 5

HTR1B

6q14.1

Mancikova et al. (2015) [33]

rs4075570

Southern European

NMTC

0.82

2.0 × 10− 4

PCNXL2

1q42.2

Son et al. (2017) [29]

rs4649295

Korean

PTC

1.45

8.53 × 10− 8

VAV3

1p13.3

Son et al. (2017) [29]

rs4915076

Korean

PTC

1.34

7.09 × 10− 8

MSRB3

12q14.3

Son et al. (2017) [29]

rs11175834

Korean

PTC

1.36

4.86 × 10− 7

SEPT11

4q21.1

Son et al. (2017) [29]

rs1874564

Korean

PTC

1.31

5.87 × 10− 7

FHIT

3p14.2

Son et al. (2017) [29]

rs9858271

Korean

PTC

1.30

2.76 × 10− 8

INSR

19p13.2

Son et al. (2017) [29]

rs7248104

Korean

PTC

1.23

1.64 × 10− 5

SLC24A6 (SLC8B1)

12q24.13

Son et al. (2017) [29]

rs16934253

Korean

PTC

1.36

0.0216

  1. aNon-Medullary Thyroid Cancer (NMTC), Papillary Thyroid Cancer (PTC), Differentiated Thyroid Cancer (DTC)