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Table 2 In silico predictions for the splicing of RAD51D wild-type (WT) and c.904-2A>T [NM_002878] (c.904-2A>T)

From: Retroperitoneal leiomyosarcoma in a female patient with a germline splicing variant RAD51D c.904-2A > T: a case report

 

WT

c.904-2A>T (Mut)

Tools

(A)

(B)

(A)

(B)

MES

100

29.4

-2.45

137.1

NetGene2

100

163.6

0

165.3

NNSplice

100

-

-

101.1

ASSP

100

67.5

-

89.6

  1. Potential effects on splicing at the original site (A) or an alternative site in exon 10 (B) predicted by each tool are shown as fold-increase of the prediction score. Raw scores and methods of prediction analysis by each tool and schemas are available in the Supplementary Information
  2. MES Max Entropy Scan, NNSplice Splice Site Prediction by Neural Network, ASSP Alternative Splice Site Predictor
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Hereditary Cancer in Clinical Practice

ISSN: 1897-4287