Participant | Sex | Age at time of study | First cancer location (age) | Second cancer location (age) | Third cancer location (age) | Fourth cancer location (age) | Cancer in first degree relatives? | Chemotherapy? /Radiation therapy? | Anti-oestrogen treatment? | Smoking regularly > 5 years | Genetic tests performed before inclusion in the study (normal results unless stated otherwise) (c) |
---|---|---|---|---|---|---|---|---|---|---|---|
A | W | 63 | Adenocarcinoma colon (30, 55) | Adenocarcinoma ovarium (47) | Adenocarcinoma endometrium (47) | CLL (55) | Yes | NA/NA | NA | NA | MLH1, MSH2, MSH6, EPCAM, PMS2. Tumour tissue BRAF neg. IHC MMR: loss of MLH1 and PMS2. |
B | W | 46 | Teratoma ovaries (30) | Rectum (33) | Breast (40) | NA | No | Yes/Yes | Yes | NA | MLH1, MSH2, MSH6, EPCAM, PMS2, BRCA1, BRCA2 |
C | W | 75 (a) | Breast (60) | Colon (62) | Lung (75) | NA | Yes | Yes/Yes | No | Yes | BRCA1, BRCA2, TP53. IHC MMR normal. |
D | W | 66 (a) | Malignant melanoma (59) | Breast (63), tubular | Endometrium (64) | Pancreas (65) | Yes | Yes/Yes | Yes | No | CDKN2A, BRCA1, BRCA2, TP53, PALB2, CHEK2, ATM, CDK4 |
E | W | 38 | Adrenal adenoma (27) | Parathyroid hyperplasia (27) | Pituitary adenoma - prolactin and GH producing (28) | Multiple neuroendocrine tumours in pancreas (30) | Yes | No/No | No | No | Endocrine tumour gene panel (d) |
F | W | 75 | Breast (59), multifocal ductal | Melanoma in situ (62, 70) | Endometrium (64) | Basalioma (76) (b) | Yes | No/No | No | Yes | PTEN. IHC MMR normal. |
G | M | 74 | Adenocarcinoma lung, 3 primaries (54, 69, 70) | Prostate (56), Gleason 7 | Rectum (57) | Carcinoid caecum (57) | No | No/Yes | Yes | No | Karyotype |
H | W | 76 | Cervix (41) | Breast (59, 69), lobular | CLL (63, 68) | Adrenal cortical carcinoma (67) | Yes | No/Yes | Yes | No | BRCA1, BRCA2, CHEK2, TP53, PTEN, STK11, CDH1. CGH-array |
I | M | 76 | Prostate (57), Gleason 7 | GIST oesophagus (68) | Colon (68) | NA | Yes | Yes/Yes | No | No | Â |
J | W | 74 | Endometrium (41) | Synovial sarcoma (54) | Breast (61), ductal | NA | Yes | No/Yes | No | Yes | BRCA1, BRCA2, CHEK2, TP53, PTEN, STK11, CDH1 |