Hereditary Cancer in Clinical Practice

Table 1 Comparison of frequently reported CNA of osteosarcoma with individual CNA of LFS patient

From: Unusual course of disease and genetic profile in Li-Fraumeni syndrome-associated osteosarcoma – a case report

Chromosome	CNA of current OS		Frequent CNA in OS
	Chromosomal regions
	gain	loss	gain	loss
1	1q23	1p36	1p32–36, 1q21–31	1q25.1
2		2p23.2–25.2		2q
3		3p, 3q22.3	3q26	3p14.1, 3q13
4		4p16.2–3		4p15.1
5			5p13-cen
6	6p-cen	6cen-q	6p12–21	6p, 6q12, 6q16, 6q21–22
7
8	8q21–24.3	8p11.22	8p, 8cen-q13, 8q12–24	8p21
9		9q33.1		9p13
10		10p		10p, 10q22–26
11			11q14
12			12p13–14, 12q11–14
13		13q		13q12.2, 13q14, 13q21–31
14	14q11.2		14q24
15
16	16p12.1–13.2	16p13.2–3	16p13
17	17p11.2	17p12–13	17p11-17p13, 17q21–25	17p13, 17q12
18				18q21–23
19	19p	19q	19p13, 19q12–13, 19q
20		20p, 20q	20q
21	21q
22		22q11.2
X,Y	Xp22.11		Xp11.2–21, Xq12

Frequently reported CNA refer to data of Rosenberg et al., Sadikovic et al., Overholtzer et al. and Man et al. Similar CNA were depicted in italics, clearly opposing CNA in fat letters. Most frequently reported CNA were underlined.

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ISSN: 1897-4287

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