Table 1 Article list used to analyzed cancer penetrance associated to weight gain and change body composition
Authors/years | Reference | Study Design | Population | Sample Size | Control Group | Outcomes Measures | Main Conclusion |
|---|---|---|---|---|---|---|---|
Bruno O. 2020 | Clinical Breast Cancer | Cohort-Trial -Study | BRCA1/2 mutation carriers | 502,0 | yes | Change in body weight and composition and lifestyle characterisics | Higher fat mass associated with ncrease BC risk with greater effects in BRCA-2 |
Qian F. 2019 | J Natl Cancer Inst | Randomized study | BRCA1/2 mutation carriers | 11,451 | yes | Anthropometric measures | Height and BMI associated to BC risk |
Kim SJ. 2018 | Int J of Epidem | Cohort-Study | BRCA1/2 mutation carriers | 3734 | yes | Changes in body weight | No association with breast cancer risk |
Manders P. 2011 | Br Can Res Treat | Cohort-Study | BRCA1/2 mutation carriers | 719,0 | yes | Anthropometric measures | Overweight and weight gain increase risk of postmenopausal breast cancer |
Kotsopoulos J. 2005 | Br Can Res | Multicenter study | BRCA1/2 mutation carriers | 3291 | yes | Changes in body weight | Weigh loss within 30 yrs reduces breast cancer risk while no association later in life |