Deciding the operation type according to mismatch repair status among hereditary nonpolyposis colorectal cancer patients: should a tailored approach be applied, or does one size fit all?

Table 5 Univariate and multivariate analyses of clinicopathological features with DFS among 181 HNPCC patients who underwent curative resection for colorectal cancer

Characteristics	n	DFS (%)			p Value	Multiple Cox
Characteristics	n	1 year	3 years	5 years	p Value	HR	95% CI	p Value
Age, years
< 40	42	95.2	90.3	87.9	0.081
≥ 40	139	92.1	79	73.9
Sex
Male	90	92.2	79.8	76.4	0.967
Female	91	93.4	83.4	77.8
MMR status
pMMR	62	95.2	77.4	71	0.08
dMMR	119	91.6	83.9	80.5
Tumor location
Right colon	94	94.7	84.9	82.7	0.02	1
Left colon	50	94	88	84		1.077	0.582–1.992	0.813
Rectum	37	86.5	64.9	54.1		1.546	0.837–2.854	0.164
Operation type
Segmental resection	129	90.7	75.7	71	< 0.001	1
Extended resection	52	98.1	96.2	92.3		0.367	0.172–0.787	0.01
Histological type
Adenocarcinoma	146	93.2	80.6	75.1	0.812
Signet ring cell/mucinous	31	93.5	87.1	87.1
Other	4	75	75	75
Histological grade
Grade I	25	100	96	2	0.164
Grade II	116	92.2	80.1	74
Grade III/IV	38	89.5	75.9	75.9
Unclassified	2	100	100	100
T stage
T0	3	100	100	100	0.056
T1	10	100	100	80
T2	14	92.9	92.9	92.9
T3	86	97.7	82.2	79.8
T4	68	85.3	75	69.1
N stage
N0	112	94.6	89.3	84.8	< 0.001	1
N1	48	91.7	76.4	72		1.521	0.839–2.759	0.167
N2	21	85.7	52.4	47.6		2.715	1.286–5.732	0.009
M stage
M0	167	95.2	85.5	81.9	< 0.001	1
M1	14	64.3	35.7	19		4.231	2.013–8.889	< 0.001

ISSN: 1897-4287