Deciding the operation type according to mismatch repair status among hereditary nonpolyposis colorectal cancer patients: should a tailored approach be applied, or does one size fit all?

Table 4 Univariate and multivariate analyses of clinicopathological features with OS among 181 HNPCC patients who underwent curative resection of CRC

Characteristics	n	OS (%)			p Value	Multiple Cox
Characteristics	n	1 year	3 years	5 years	p Value	HR	95% CI	p Value
Age, years
< 40	42	95.2	90.3	90.3	0.05	1
≥ 40	139	95	83.4	78.3		2.176	0.933–5.075	0.072
Sex
Male	90	94.5	85.6	81.2	0.688
Female	91	95.5	84.3	80.9
MMR status
pMMR	62	95.2	77.4	71	0.002	1
dMMR	119	95	89	86.4		0.479	0.257–0.894	0.021
Tumor location
Right colon	94	95.7	88.1	86	0.001	1
Left colon	50	98	92	90		1.254	0.620–2.537	0.53
Rectum	37	89.2	67.6	56.8		1.302	0.628–2.702	0.478
Operation type
Segmental resection	129	93	79.6	74.9	0.003	1
Extended resection	52	100	98.1	96.2		0.501	0.219–1.150	0.103
Histological type
Adenocarcinoma	146	95.9	84.8	79.9	0.993
Signet ring cell/mucinous	31	93.5	87.1	87.1
Other	4	75	75	75
Histological grade
Grade I	25	100	100	92	0.509
Grade II	116	94	82.6	78.3
Grade III/IV	38	94.7	81.2	81.2
Unclassified	2	100	100	100
T stage
T0	3	100	100	100	0.073
T1	10	100	100	80
T2	14	92.9	92.9	92.9
T3	86	98.8	84.5	82.1
T4	68	89.7	80.9	76.5
N stage
N0	112	97.3	93.8	90.2	< 0.001	1
N1	48	93.7	78.5	74.1		1.343	0.655–2.756	0.421
N2	21	85.7	52.4	47.6		3.605	1.623–8.009	0.002
M stage
M0	167	97.6	89.1	86.1	< 0.001	1
M1	14	64.3	35.7	19		7.723	3.362–17.742	< 0.001

ISSN: 1897-4287