Table 1 Basic characteristics and clinicopathological features among 186 HNPCC patients
|  | dMMR (n = 121) | pMMR (n = 65) | p Value |
|---|---|---|---|
Age (mean ± SD), years | 47.54 ± 12.39 | 54.62 ± 13.67 | < 0.001 |
Sex | |||
 Male | 59 (48.8) | 34 (52.3) | 0.645 |
 Female | 62 (51.2) | 31 (47.7) |  |
Cancer location | |||
 Right colon | 74 (61.2) | 22 (33.8) | < 0.001 |
 Left colon | 30 (24.8) | 20 (30.8) |  |
 Rectum | 17 (14.0) | 23 (35.4) |  |
Histological type | |||
 Adenocarcinoma | 94 (77.7) | 87 (87.7) | 0.058* |
 Signet ring cell | 2 (1.7) | 2 (3.1) |  |
 Mucinous | 22 (18.2) | 5 (7.7) |  |
 NET | 0 (0) | 1 (1.5) |  |
 Other | 3 (2.5) | 0 (0) |  |
Histological grade | |||
 Grade I | 17 (14) | 10 (15.4) | 0.048* |
 Grade II | 70 (57.9) | 47 (72.3) |  |
 Grade III/IV | 31 (25.6) | 8 (12.3) |  |
 Unclassified | 3 (2.5) | 0 (0) |  |
Operation type | |||
 Segmental resection | 78 (64.5) | 51 (78.5) | 0.021* |
 Extended resection | 41 (33.9) | 11 (16.9) |  |
 Local resection | 2 (1.7) | 3 (4.6) |  |
T stage | |||
 T0 | 2 (1.7) | 1 (1.6) | 0.397 |
 T1 | 6 (5.0) | 5 (7.8) |  |
 T2 | 10 (8.3) | 4 (6.3) |  |
 T3 | 52 (43.0) | 35 (54.7) |  |
 T4 | 51 (42.1) | 19 (29.7) |  |
N stage | |||
 N0 | 83 (68.6) | 32 (50) | 0.013 |
 N1 | 29 (24.0) | 19 (29.7) |  |
 N2 | 9 (7.4) | 13 (20.3) |  |
M stage | |||
 M0 | 10 (8.3) | 6 (9.2) | 0.823 |
 M1 | 111 (91.7) | 59 (90.8) |  |