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Table 2 The details of germline BRCA2 mutations and the number of carriers for lung cancer patients

From: Characteristics of BRCA1/2 pathogenic germline mutations in chinese NSCLC patients and a comparison with HBOC

Mutations Mutation Type Number of carriers in Lung Cancer Number of carriers in Breast and Ovary Cancer
Q1037* Nonsense 3 48
S1722fs Frameshift 2 25
K936fs Frameshift 1 16
F2801fs Frameshift 1 16
K157Sfs*24 Frameshift 1 12
A938fs Frameshift 1 12
N3024fs Frameshift 1 10
M815fs Frameshift 1 7
S1900* Nonsense 1 7
N433fs Frameshift 1 6
R2336L Missense 2 6
N2135fs Frameshift 1 5
T3033fs Frameshift 1 5
S2120* Nonsense 1 4
R2318* Nonsense 1 4
I591fs Frameshift 1 3
Q1987* Nonsense 1 3
Exon24-splice Splice site variant 1 3
I605fs Frameshift 1 2
S780* Nonsense 1 2
L929* Nonsense 1 2
Y949fs Frameshift 1 2
M2235fs Frameshift 1 2
S2984* Nonsense 1 2
G3134Afs*29 Frameshift 1 2
D252fs Frameshift 2 1
P1145* Nonsense 1 1
L1908fs Frameshift 1 1
N2137fs Frameshift 1 1
Exon16-splice Splice site variant 2 1
Q2530* Nonsense 1 1
L2573* Nonsense 1 1
exon21-splice Splice site variant 1 1
8487+1G>C Splice site variant 1 1
K3004fs Frameshift 1 1
R3052W Missense 1 1
M3118fs Frameshift 1 1
S158* Nonsense 1 0
D306fs Frameshift 1 0
E357* Nonsense 1 0
T598fs Frameshift 1 0
E790* Nonsense 1 0
Y828* Nonsense 1 0
N1055fs Frameshift 1 0
D1210fs Frameshift 1 0
K1239fs Frameshift 1 0
D1476fs Frameshift 1 0
I1485Nfs*3 Frameshift 1 0
L1616fs Frameshift 1 0
E1625fs Frameshift 1 0
E1646Nfs*19 Frameshift 1 0
Y1661* Nonsense 1 0
V1681fs Frameshift 1 0
R1694* nonsense 1 0
K1964* Nonsense 1 0
H1966fs Frameshift 1 0
I2149fs Frameshift 1 0
G2274fs Frameshift 1 0
R2896fs Frameshift 1 0
E3258fs Frameshift 1 0