Table 2 The details of germline BRCA2 mutations and the number of carriers for lung cancer patients

Q1037*

Nonsense

3

48

S1722fs

Frameshift

2

25

K936fs

Frameshift

1

16

F2801fs

Frameshift

1

16

K157Sfs*24

Frameshift

1

12

A938fs

Frameshift

1

12

N3024fs

Frameshift

1

10

M815fs

Frameshift

1

7

S1900*

Nonsense

1

7

N433fs

Frameshift

1

6

R2336L

Missense

2

6

N2135fs

Frameshift

1

5

T3033fs

Frameshift

1

5

S2120*

Nonsense

1

4

R2318*

Nonsense

1

4

I591fs

Frameshift

1

3

Q1987*

Nonsense

1

3

Exon24-splice

Splice site variant

1

3

I605fs

Frameshift

1

2

S780*

Nonsense

1

2

L929*

Nonsense

1

2

Y949fs

Frameshift

1

2

M2235fs

Frameshift

1

2

S2984*

Nonsense

1

2

G3134Afs*29

Frameshift

1

2

D252fs

Frameshift

2

1

P1145*

Nonsense

1

1

L1908fs

Frameshift

1

1

N2137fs

Frameshift

1

1

Exon16-splice

Splice site variant

2

1

Q2530*

Nonsense

1

1

L2573*

Nonsense

1

1

exon21-splice

Splice site variant

1

1

8487+1G>C

Splice site variant

1

1

K3004fs

Frameshift

1

1

R3052W

Missense

1

1

M3118fs

Frameshift

1

1

S158*

Nonsense

1

0

D306fs

Frameshift

1

0

E357*

Nonsense

1

0

T598fs

Frameshift

1

0

E790*

Nonsense

1

0

Y828*

Nonsense

1

0

N1055fs

Frameshift

1

0

D1210fs

Frameshift

1

0

K1239fs

Frameshift

1

0

D1476fs

Frameshift

1

0

I1485Nfs*3

Frameshift

1

0

L1616fs

Frameshift

1

0

E1625fs

Frameshift

1

0

E1646Nfs*19

Frameshift

1

0

Y1661*

Nonsense

1

0

V1681fs

Frameshift

1

0

R1694*

nonsense

1

0

K1964*

Nonsense

1

0

H1966fs

Frameshift

1

0

I2149fs

Frameshift

1

0

G2274fs

Frameshift

1

0

R2896fs

Frameshift

1

0

E3258fs

Frameshift

1

0