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Table 1 The details of germline BRCA1 mutations and the number of carriers for lung cancer patients

From: Characteristics of BRCA1/2 pathogenic germline mutations in chinese NSCLC patients and a comparison with HBOC

Mutations

Mutation Type

Number of carriers in Lung Cancer

Number of carriers in Breast and Ovary Cancer

I1824Dfs*3

Frameshift

2

134

Exon4-splice

Splice site variant

1

13

R1443*

Nonsense

1

11

E489*

Nonsense

1

9

E1158*

Nonsense

1

8

L502Afs*2

Frameshift

1

4

E720*

Nonsense

1

3

S1503*

Nonsense

1

2

Exon3-splice

Splice site variant

1

1

H318Lfs*24

Frameshift

1

1

T715fs

Frameshift

1

1

L1209*

Nonsense

1

1

F1571fs

Frameshift

1

1

G1743fs

Frameshift

1

1

K339Rfs*2

Frameshift

1

0

E755fs

Frameshift

1

0

Q934*

Nonsense

1

0

K1079*

Nonsense

1

0

Y1666*

Nonsense

1

0