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Table 1 The details of germline BRCA1 mutations and the number of carriers for lung cancer patients

From: Characteristics of BRCA1/2 pathogenic germline mutations in chinese NSCLC patients and a comparison with HBOC

Mutations Mutation Type Number of carriers in Lung Cancer Number of carriers in Breast and Ovary Cancer
I1824Dfs*3 Frameshift 2 134
Exon4-splice Splice site variant 1 13
R1443* Nonsense 1 11
E489* Nonsense 1 9
E1158* Nonsense 1 8
L502Afs*2 Frameshift 1 4
E720* Nonsense 1 3
S1503* Nonsense 1 2
Exon3-splice Splice site variant 1 1
H318Lfs*24 Frameshift 1 1
T715fs Frameshift 1 1
L1209* Nonsense 1 1
F1571fs Frameshift 1 1
G1743fs Frameshift 1 1
K339Rfs*2 Frameshift 1 0
E755fs Frameshift 1 0
Q934* Nonsense 1 0
K1079* Nonsense 1 0
Y1666* Nonsense 1 0