Fig. 3

a Reason for diagnosis of Lynch syndrome over time, per year, n = 305; Data were collected on patients registered at the Hereditary Gastrointestinal Cancer Unit, Karolinska University Hospital, Solna, Sweden between the period June 1994–September 2018 (Figure created with Microsoft Excel). In 1994, 1% (n = 3) patients were diagnosed due to predictive testing. In 1995, 0% (n = 0) patients were diagnosed. In 1996, 0.3% (n = 1) were diagnosed due to family history and 0.7% (n = 2) due to predictive testing. In 1997, 0.3% (n = 1) were diagnosed due to family history and 1.3% (n = 4) were diagnosed due to predictive testing. In 1998, 0.3% (n = 1) were diagnosed due to family history. In 1999, 0.3% (n = 1) were diagnosed due to predictive testing. In 2000, 0.3% (n = 1) were diagnosed due to predictive testing and 0.3% (n = 1) were diagnosed due to malignancy. In 2001, 0.3% (n = 1) were diagnosed due to predictive testing and 0.3% (n = 1) were diagnosed due to malignancy. In 2002, 1.3% (n = 4) were diagnosed due to predictive testing and 0.7% (n = 2) due to malignancy. In 2003, 1% (n = 3) were diagnosed due to predictive testing and 0.3% (n = 1) were diagnosed due to malignancy. In 2004, 0.7% (n = 2) were diagnosed due to family history, 3% (n = 9) were diagnosed due to predictive testing and 1% (n = 3) were diagnosed due to malignancy. In 2005, 2% (n = 6) were diagnosed due to predictive testing and 0.7% (n = 2) were diagnosed due to malignancy. In 2006, 0.3% (n = 1) were diagnosed due to family history, 3.6% (n = 11) due to predictive testing and 2% (n = 6) due to malignancy. In 2007, 0.7% (n = 2) were diagnosed due to family history, 1.3% (n = 4) were diagnosed due to predictive testing and 0.3% (n = 1) were diagnosed due to malignancy. In 2008, 0.3% (n = 1) were diagnosed due to family history, 3.6% (n = 11) were diagnosed due to predictive testing and 1% (n = 3) were diagnosed due to malignancy. In 2009, 0.3% (n = 1) were diagnosed due to family history, 2.3% (n = 7) were diagnosed due to predictive testing and 0.3% (n = 1) were diagnosed due to malignancy. In 2010, 0.3% (n = 1) were diagnosed due to family history, 2.6% (n = 8) were diagnosed due to predictive testing and 2% (n = 6) were diagnosed due to malignancy. In 2011, 0.3% (n = 1) were diagnosed due to family history, 3.9% (n = 12) were diagnosed due to predictive testing and 0.7% (n = 2) were diagnosed due to malignancy. In 2012, 1% (n = 3) were diagnosed due to family history, 5.2% (n = 16) were diagnosed due to predictive testing and 2.3% (n = 7) were diagnosed due to malignancy. In 2013, 1% (n = 3) were diagnosed due to family history, 3.9% (n = 12) were diagnosed due to predictive testing and 3.9% (n = 12) were diagnosed due to malignancy. In 2014, 1.3% (n = 4) were diagnosed due to family history, 5.2% (n = 16) were diagnosed due to predictive testing and 2.6% (n = 8) were diagnosed due to malignancy. In 2015, 0.3% (n = 1) were diagnosed due to family history, 6.9% (n = 21) were diagnosed due to predictive testing and 3.6% (n = 11) were diagnosed due to malignancy. In 2016, 0.3% (n = 1) were diagnosed due to family history, 3.9% (n = 12) were diagnosed due to predictive testing and 3.3% (n = 10) were diagnosed due to malignancy. In 2017, 1% (n = 3) were diagnosed due to family history, 4.9% (n = 15) were diagnosed due to predictive testing and 2.6% (n = 8) were diagnosed due to malignancy. In 2018, 3.6% (n = 11) were diagnosed due to predictive testing and 1% (n = 3) were diagnosed due to malignancy. b. Reason for diagnosis of Lynch syndrome over timeperiods, n = 305; Data were collected on patients registered at the Hereditary Gastrointestinal Cancer Unit, Karolinska University Hospital, Solna, Sweden between the period June 1994–September 2018 (Figure created with Microsoft Excel). In 1994–1999, 77% (n = 10/13) patients were diagnosed due to family history and 23% (n = 3/13) were diagnosed due to predictive testing. In 2000–2009, 25% (n = 21/85) were diagnosed due to malignancy, 67% (n = 57/85) were diagnosed due to predictive testing and 8% (n = 7/85) were diagnosed due to family history. In 2010–2018, 32% (n = 67/207) were diagnosed due to malignancy, 60% (n = 123/207) were diagnosed due to predictive testing and 8% (n = 17/207) were diagnosed due to family history