Table 1 Characteristics of the CHEK2 c.1100del index PV carriers (N = 66)
Breast cancer | N | Mean age diagnosis | Min | max |
|---|---|---|---|---|
Breast cancer | 64 | 44.8 | 21 | 64 |
2nd breast cancer | 18 | 52.1 | 35 | 67 |
Other cancer | 7 | 54.2 | 39 | 66 |
Ovarian cancer (borderline) | 3 (2) | 50.3 | 39 | 65 |
Skin (1 melanoma; 3 undefined) | 4 | 58 | 53 | 66 |
Receptor status | Pos (%) | Neg. (%) | Some amplifaction (%) | |
Oesterogen (N = 48) | 44 (91.7%) | 4 (8.3%) | ||
Progesteron (N = 47) | 37 (78.7%) | 10 (21.3%) | ||
HER2neu amplification (N = 35) | 9 (25.7%) | 24 (68.6%) | 2 (5.7%) | |
Ductal | Lobular | Ductal with lobular features | ||
Histopathology known (N = 53) | 45 (84.9%) | 5 (9.4%) | 3 (5.7%) | |
Family history | Yes (%) | No (%) | Unknown (%) | |
Breast cancer | 51 (77.3%) | 14 (21.2%) | 1 (1.5%) | |
1st-degree only | 23 | |||
2nd-degree only | 14 | |||
Both 1st- and 2nd-degree | 13 | |||
Families with other cancers in 1st degree relatives | 32 (48.5%) | 33 (50.0%) | 1 (1.5%) | |
N Cancers in 1st-degree relativesa | 40 (60.6%) | |||