Table 2 Risk of dying from cancer in each organ before 80 years of age calculated as cumulative risk 70 years multiplied by [1-(10 years survival)] [14], both genders combined. Path_PMS2 carriers not included because too few prospective cancers before 70 years of age for meaningful calculations
From: The Prospective Lynch Syndrome Database reports enable evidence-based personal precision health care
ICD9 | Organ | Cumulative incidence by age 70 years | 10 years survival | Risk of dying from before 80 years (cumulative incidence 70 years)∙[1-(survival)] | ||||
|---|---|---|---|---|---|---|---|---|
path_MLH1 | path_MSH2 | path_MSH6 | path_MLH1 | path_MSH2 | path_MSH6 | |||
153 | Colon | 42% | 40% | 14% | 88% | 5% | 5% | 2% |
154 | Sigmoid and rectum | 9% | 14% | 5% | 70% | 3% | 4% | 2% |
182 | Endometrium | 40% | 53% | 46% | 93% | 3% | 4% | 3% |
183 | Ovaries | 10% | 17% | 13% | 74% | 3% | 4% | 3% |
151 | Stomach | 6% | 4% | 1% | 61% | 2% | 2% | 0 |
152 | Duodenum | 4% | 2% | 0 | 67% | 1% | 1% | 0 |
156 | Bile duct and gall bladder | 4% | 0 | 0 | 14% | 3% | 0 | 0 |
157 | Pancreas | 4% | 1% | 1% | 0 | 4% | 1% | 1% |
188 | Urinary bladder | 4% | 6% | 4% | 81% | 1% | 1% | 1% |
189 | Ureter and kidney | 4% | 16% | 3% | 71% | 1% | 5% | 1% |
174 | Breast | 12% | 12% | 13% | 89% | 1% | 1% | 1% |
185 | Prostate | 13% | 13% | 4% | 80% | 3% | 3% | 1% |
191 | Brain | 1% | 2% | 1% | 22% | 1% | 2% | 1% |