Ubiquitous neurocognitive dysfunction in familial adenomatous polyposis: proof-of-concept of the role of APC protein in neurocognitive function

Cruz-Correa, Marcia Roxana; Sala, Ana Cecilia; Cintrón, Beatriz; Hernández, Jessica; Olivera, Myrta; Cora, Adrian; Moore, Constance M.; Luciano, Carlos A.; Soto-Salgado, Marievelisse; Giardiello, Francis M.; Hooper, Stephen R.

doi:10.1186/s13053-020-0135-3

Hereditary Cancer in Clinical Practice

Table 3 Comparisons of FAP Severity Groups on Neurocognitive Functions

From: Ubiquitous neurocognitive dysfunction in familial adenomatous polyposis: proof-of-concept of the role of APC protein in neurocognitive function

Measure	Attenuated FAP Group (n = 9)		Classic FAP Group (n = 17)		p-value*	Simple LRM(coefficients)	p-value	Adjusted multivariate LRM** (coefficients)	p-value	Adjusted multivariate LRM*** (coefficients)	p-value
Measure	Mean	SD	Mean	SD	p-value*	Simple LRM(coefficients)	p-value	Adjusted multivariate LRM** (coefficients)	p-value	Adjusted multivariate LRM*** (coefficients)	p-value
TONI-4 IQ	91.2	4.5	90.2	6.3	0.662	−1.0	0.662	−1.0	0.670	−0.9	0.709
Batería III clusters
Verbal ability	89.7	5.5	87.4	8.7	0.479	−2.3	0.479	−2.3	0.504	−2.0	0.566
Thinking ability	81.8	10.0	79.9	10.9	0.669	−1.9	0.669	−2.0	0.671	−1.8	0.704
Cognitive efficiency	87.2	6.4	77.8	13.0	0.054	−9.4	0.054	−9.4	0.064	−9.2	0.076
Long-term memory	65.0	16.2	67.7	13.6	0.655	2.7	0.655	2.4	0.677	2.6	0.666
Processing speed	92.9	7.9	81.0	16.0	0.048	−11.9	0.048	−12.1	0.045	−11.4	0.056
Phonemic awareness	91.1	11.1	87.3	10.7	0.400	−3.8	0.400	−3.8	0.419	−4.2	0.379
Working memory	88.6	6.6	82.2	11.9	0.154	−6.3	0.154	−6.2	0.168	−6.1	0.189
Cognitive fluency	82.4	11.0	76.1	12.5	0.210	−6.4	0.210	−6.5	0.164	−6.2	0.193
Executive processes	84.8	10.8	83.2	15.3	0.791	−1.5	0.791	−1.6	0.781	−1.0	0.862
BRIEF-Adult
Inhibit	50.4	5.9	48.8	8.8	0.657	−1.6	0.657	−1.3	0.712	−0.5	0.886
Shift	57.1	8.1	49.1	10.4	0.052	−8.1	0.068	−7.6	0.055	−7.9	0.058
Emotional control	52.5	6.1	51.0	9.8	0.519	−1.5	0.696	−1.2	0.742	−1.3	0.726
Self-monitor	52.4	9.3	48.9	8.1	0.229	−4.4	0.249	−4.0	0.253	−5.2	0.134
Initiate	55.8	12.2	47.9	9.5	0.070	−7.9	0.095	−7.4	0.082	−7.9	0.081
Working memory	52.9	12.6	54.1	11.4	0.735	1.2	0.818	1.8	0.663	1.3	0.760
Plan/Organize	54.3	12.3	48.3	9.9	0.176	−5.9	0.214	−5.3	0.158	−5.5	0.162
Task monitor	54.8	10.9	49.9	11.8	0.310	−4.8	0.345	−4.1	0.287	−3.6	0.369
Organization of materials	50.8	8.6	49.4	8.2	0.706	−1.4	0.706	−1.1	0.744	−0.5	0.882
Behavior regulation index	53.6	6.7	49.4	9.6	0.281	−4.2	0.281	−3.7	0.270	−3.8	0.283
Metacognitive index	53.9	11.5	49.7	10.5	0.443	−4.2	0.380	−3.6	0.344	−3.6	0.361
Global executive composite	54.1	9.2	49.6	10.2	0.297	−4.6	0.300	−4.0	0.253	−4.0	0.276

*p-values from T-test or Wilcoxon rank-sum (Mann-Whitney) test; **Adjusted by age and gender; ***Adjusted by age, gender and education

Back to article page

ISSN: 1897-4287

Contact us

General enquiries: journalsubmissions@springernature.com